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Fig. 1 | Beni-Suef University Journal of Basic and Applied Sciences

Fig. 1

From: The anti-tumor drug 2-hydroxyoleic acid regulates the oncogenic potassium channel Kv10.1

Fig. 1

2OHOA increases Kv10.1 currents in a voltage-dependent manner. A, B Representative recordings of Kv10.1 currents before (A) and after application of 200 µM 2OHOA (B), from the same cell. Currents were evoked by 500 ms depolarizing steps to test potentials ranging from -80 to + 90 mV in 10 mV increments from a holding potential of -100 mV. C normalized I-V relationships for currents measured at the end of the 500 ms pulses before (squares) and after 2OHOA (circles). D Kv10.1 current increase by 2OHOA plotted as a function of the test potential. Data are represented as mean ± SEM (n = 13 cells)

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