Fig. 2
From: The anti-tumor drug 2-hydroxyoleic acid regulates the oncogenic potassium channel Kv10.1
Effect of 2OHOA on the voltage-dependence of activation, activation kinetics and Cole-More shift of Kv10.1 channel. A conductance-voltage (G–V) curves before (squares) and after application of 200 µM 2OHOA (circles). The V1/2 values were 5.9 ± 0.9 mV and − 6.2 ± 1.1 mV for currents recorded before and after 2OHOA, respectively (n = 13 cells). B time constant of activation kinetics as a function of test potential before (squares) and after 2OHOA application (circles; n = 9 cells). C, D Representative Kv10.1 currents at + 60 mV evoked with the protocol shown inset in control (C) and 200 µM 2OHOA treated cells (D). similar results were obtained in five more cells. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01, NS: Not significant