Fig. 4From: The anti-tumor drug 2-hydroxyoleic acid regulates the oncogenic potassium channel Kv10.12OHOA and astemizole synergistically decreases MCF-7 cells proliferation. A–C proliferation of MCF-7 cells treated with different concentrations of 2OHOA (12.5, 25, 50, 100, 200, 400 and 1000 µM), 5 µM astemizole and the combination 200 µM 2OHOA and 5 µM astemizole determined at 24 (A), 48 (B) and 72 h (C). Asterisks indicate significant effects compared with controls (*p < 0.05; **p < 0.01), # indicates a significant effect of the combination of 200 µM 2OHOA + 5 µM Astemizole compared to 200 µM 2OHOA or 5 µM Astemizole applied alone (#p < 0.05; ##p < 0.01), NS: Not significant. Data are represented as mean ± SEM (n = 5)Back to article page