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Beni-Suef University Journal of Basic and Applied Sciences
Fig. 3 | Beni-Suef University Journal of Basic and Applied Sciences

Fig. 3

From: Interleukin-22 and interleukin-33 show up-regulated levels in the serum of patients with mild/moderate Coronavirus disease 2019

Fig. 3

Reciever operating characteristic (ROC) curve analysis of IL-22 and IL-33 in COVID-19 cases versus healthy controls. IL-22 (area under the curve [AUC] = 0.95; 95% confidence interval [CI] = 0.908–0.992; p < 0.001; cut-off point = 17.3 pg/mL; Youden index [YI] = 0.88; sensitivity = 95.9%; specificity = 92.2%) and IL-33 (AUC = 0.892; 95% CI = 0.839–0.945; p < 0.001; cut-off point = 30.7 pg/mL; YI = 0.8; sensitivity = 90.0%; specificity = 90.0%) showed excellent prognostic value in differentiating patients from controls. The AUC is estimated through ROC analysis to describe the overall performance of a biomarker (i.e. cytokine serum level) to discriminate between cases with and without the disease under study. In general, the AUC value follows the following scheme: 0.50–0.59 (no discrimination), 0.60–0.69 (poor discrimination), 0.70–0.79 (acceptable), 0.80–0.89 (excellent) and ≥ 0.9 (outstanding)

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