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Table 2 Serum interleukin (IL-22 and IL-33) concentrations stratified by age group, gender, and body mass index in COVID-19 cases, controls, and all participants (patients plus controls)

From: Interleukin-22 and interleukin-33 show up-regulated levels in the serum of patients with mild/moderate Coronavirus disease 2019

Group

Median (IQR); pg/mL

COVID-19; n = 90

Controls; n = 90

All; n = 180

IL-22

IL-33

IL-22

IL-33

IL-22

IL-33

Age; year

20–39

18.9 (18.0–19.3)

40.1 (36.3–43.3)

13.9 (12.7–14.9)

24.0 (23.0–28.0)

16.8 (13.8–18.8)

31.4 (23.5–40.2)

40–65

18.5 (18.0–19.2)

37.7 (34.9–42.0)

13.9 (12.1–15.5)

24.1 (23.0–25.9)

17.0 (13.7–18.5)

30.7 (23.9–39.3)

p-value

0.422

0.379

0.913

0.974

0.938

0.911

Gender

Male

18.5 (18.0–19.2)

39.3 (36.4–43.5)

14.1 (12.7–14.9)

24.0 (23.0–26.2)

16.6 (13.8–18.4)

29.8 (23.7–39.6)

Female

19.1 (18.1–19.5)

37.4 (35.3–42.1)

13.8 (12.1–15.2)

24.1 (22.6–26.1)

17.2 (13.5–19.1)

33.0 (24.1–39.9)

p-value

0.141

0.352

0.585

0.797

0.518

0.558

BMI

NWT

19.2 (18.1–19.5)

39.5 (34.9–43.4)

13.7 (12.4–15.2)

25.1 (23.3–28.9)

16.3 (13.5–19.1)

29.8 (24.1–38.0)

O/O

18.5 (17.9–19.2)

37.8 (36.2–42.7)

14.1 (12.1–14.9)

23.8 (22.1–25.8)

17.2 (14.1–18.5)

32.4 (23.7–39.7)

p-value

0.04

0.981

0.517

0.072

0.868

0.874

  1. IL Interleukin, IQR Interquartile range, BMI Body mass index, NWT Normal-weight; O/O Overweight/obese, p Two-tailed probability (significant p-value is indicated in bold). Mann–Whitney U test was used to assess significant differences between medians