Table 2 Natural therapies associated with sickle cell disease
From: Recent progress in the treatment of sickle cell disease: an up-to-date review
Serial no. | Biological Source | Family | Major chemical constituents | Inducer | Pharmacological effects | References |
|---|---|---|---|---|---|---|
1 | Angelica arcangelica | Apiaceae | α-pinene, myrcene, camphene, β- limonene, phellandrene, caryophyllene, carvone, borneol, and others | Angelicin | Erythroid differentiation and HbF induction | [114] |
2 | Aegle marmelos | Rutaceae | Furocoumarins like methyl ester of alloimperatorin, xanthotoxol with several flavonoids, rutin, and marmesin | Bergaptene | Erythroid differentiation of K562 cells and HbF induction | [115] |
3 | Citrus bergamia | Rutaceae | Naringin, neoeriocitrin, ponceritin, neohesperidin, mitrocin, melitidin, brutieridin, miriflin, and bergamottin | Citropten and bergapten | Erythroid differentiation and HbF production | [116] |
4 | Trichosanthes kirilowii | Cucurbitaceae | 5-hydroxymethyl-2-furfural, Trichosanthin, vanillic acid, chrysoeriol, 4'-hydroxyscutellarin, and alpha-spinasterol | Cucurbitacin D | HbF production and Erythroid differentiation of K562 cells | [117] |
5 | Terminalia catappa | Combretaceae | Magnesium, manganese, iron, calcium, and zinc | Distilled water active fraction | Erythropoiesis, cell proliferation, and transcription | [118] |
6 | Vitis vinifera | Vitaceae | Catechin, Reservetol, gallic acid, epicatechin and quercetin, | Resveratrol | HbF induction | [119] |
7 | Streptomyces hygroscopicus | Streptomycetaceae | Ascomycin and rapamycin | Rapamycin | HbF induction | [119] |
8 | Streptomyces species | Streptomycetaceae | Daptomycin, Chloramphenicol, and Mithramycin | Mithramycin | HbF production | [116] |