Fig. 6

The model regulating cell proliferation by super enhancer. a Pre-disruption model of Klf6-related SE. When Klf6-related SE is not disrupted, it upregulates Klf6 expression and induces cellular proliferation. b Post-disruption model of Klf6-related SE. When Klf6-related SE is disrupted, it upregulates Klf6-SV2 expression which leads to p21-mediated growth inhibition. The size of the arrow in the figure represents the relative expression intensity of the target gene. In other words, an arrow indicated by a thick line means strong gene expression compared to a thinly marked arrow