The association of estrogen-signaling pathways and susceptibility to open-angle glaucoma

Beni-Suef University Journal of Basic and Applied Sciences

Table 3 Meta-analysis for the association between ER polymorphisms and the risk of OAG

Contrast	Number of studies	OR	95% CI	I² (%)	P value
ERα rs12154178
A vs C	2	0.97	0.72–1.31	0	0.84
AA vs AC/CC	2	0.98	0.70–1.38	0	0.92
CC vs AA/AC	2	1.60	0.72–3.59	0	0.25
CC vs AA	2	1.58	0.70–3.58	0	0.27
CC vs AC	2	1.63	0.71–3.74	0	0.25
ERα rs1884054
A vs C	2	1.01	0.75–1.36	0	0.95
AA vs AC/CC	2	1.02	0.72–1.42	0	0.93
CC vs AA/AC	2	0.86	0.45–1.63	21	0.64
CC vs AA	2	0.85	0.41–1.77	32	0.67
CC vs AC	2	0.96	0.79–1.15	0	0.61
ERβ rs1268656
T vs G	2	1.49	1.01–2.21	0	0.05
TT vs GT/GG	2	1.58	0.83–3.02	62	0.17
GG vs TT/GT	2	0.73	0.49–1.08	1	0.11
GG vs TT	2	2.08	0.88–4.88	0	0.09
GG vs GT	2	1.66	0.67–4.11	0	0.27
ERβ rs7159462
C vs T	2	0.70	070–1.10	0	0.12
CC vs CT/TT	2	0.66	0.42–1.05	0	0.08
TT vs CC/CT	2	4.05	0.73–22.30	0	0.11
TT vs CC	2	4.27	0.77–23.55	0	0.10
TT vs CT	2	3.07	0.53–17.72	0	0.21
ERβ rs1256031
C vs T	2	1.20	0.99–1.46	0	0.07
CC vs TC/TT	2	1.15	0.84–1.58	0	0.37
TT vs CC/TC*	2	0.64	0.47–0.88	0	0.006
TT vs CC	2	0.70	0.48–1.03	0	0.07
TT vs TC*	2	0.61	0.44–0.86	0	0.005
ERβ rs4986938
G vs A*	2	1.37	1.04–1.82	0	0.03
GG vs GA/AA	2	1.37	1.00–1.88	0	0.05
AA vs GG/GA	2	0.51	0.21–1.24	0	0.14
AA vs GG	2	0.48	0.20–1.16	0	0.10
AA vs GA	2	0.63	0.25–1.59	0	0.33