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Table 1 Recurrent mutation distribution in the SARS-CoV-2 genome in African population

From: Mutational hotspots and conserved domains of SARS-CoV-2 genome in African population

   S protein N protein ORF3 ORF8 nsp2 nsp5 nsp6 nsp12
Country Viral samples N501Y D614G S194L R203K G204R Q57H L84S T265I G3278S L3606F P4715L
Global 230,845 607 214,571 13,479 77,609 76,904 49,109 6142 31,802 4923 15,027 214,154
Africa 3045 103 2881 188 1539 1516 383 169 197 191 152 2787
Algeria 3   3     3   3    3
Benin 12   8     5 4 5    7
Botswana 1   1     1   1    1
Burkina Faso 50   38   13 13 3 32     18
Congo 8   8     7      8
Côte D’Ivoire 43   41     10 28 3   5 15
DR Congo 186   178   16 16 14 4   7 35 178
Egypt 150   143 3 24 3 94 6 2 12   94
Equatorial Guinea 45   45 1        2 45
Gabon 4   2     1 2 1    2
Gambia 235   234   83 83 16   12   3 234
Ghana 15   7   3 3 2 8     7
Kenya 25   19   2 2 1 3 1   3 19
Madagascar 6   4   2 2 2     2 4
Mali 22   7     6 13 3   2 8
Morocco 59   59   22 22 14   10   1 59
Mozambique 2   2   1 1 1   1    2
Nigeria 140   120   66 65 41 11 9 2 13 121
Reunion 4   4     1   1    4
Rwanda 5   5 1    1      5
Senegal 83   77   14 14 16 4 12   5 77
Sierra Leone 10   5   2 2 2 4 2   1 5
South Africa 1735 103 1730 177 1241 1240 111 1 111 160 60 1730
Tunisia 43   39 1 8 8 20 2 9 2 5 39
Uganda 121   64 1 14 14 5 47 5 8 13 64
Zambia 1   1   1 1       1
Zimbabwe 37   37 4 27 27 6   6   2 37
Total 3045 103 2881 188 1539 1516 383 169 197 191 152 2787
  1. 3045 complete SARS-CoV-2 sequences from 27 African countries were mined and analyzed (all recurrent mutations observed are presented as Supplementary file S2)
  2. *Highly recurrent mutations were observed in ORF1ab polyprotein (nsp 5, 6, and 12), S protein (S1 domain), ORF3, and N protein, flagging these regions as SARS-CoV-2 mutational hotspots