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Beni-Suef University Journal of Basic and Applied Sciences
Fig. 1 | Beni-Suef University Journal of Basic and Applied Sciences

Fig. 1

From: Antagonization of monoamine reuptake transporters by agmatine improves anxiolytic and locomotive behaviors commensurate with fluoxetine and methylphenidate

Fig. 1

Potential mechanism of action of agmatine as monoamine reuptake inhibitor. Agmatine (AGM) may block serotonin reuptake transporter (SERT) found on presynaptic neuron. This leads to increase in serotonin (5-HT) levels at synaptic cleft thus induces cellular response at post-synaptic neuron. AGM may also inhibit dopamine reuptake transporter (DAT) and norepinephrine reuptake transporter (NET) at pre-synapse. Similar to serotonin, inhibition of DAT and NET leads to elevated levels of dopamine (D) and norepinephrine (NE) at synaptic cleft. The mechanism of action of AGM at monoamine reuptake transporters is similar to fluoxetine (FLX) and methylphenidate (MPD) at SERT, DAT, and NET, respectively. Consequently, monoamines bind to their specific post-synaptic receptors efficiently and lead to improved mood and anxiolytic and learning behaviors

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