Table 2 Summary of frontotemporal dementia susceptible genes and their associated disorders retrieved from NeuroDNet
FTD susceptible genes | Associated disorders | UniProt ID |
|---|---|---|
C9orf72 | Amyotrophic lateral sclerosis (OMIM: 105400) Frontotemporal dementia (OMIM: 600274) | Q96LT7 |
CHMP2B | Frontotemporal dementia (OMIM: 600274) | Q9UQN3 |
GRN | Multiple sclerosis (OMIM: 126200) Frontotemporal dementia (OMIM: 600274) | P28799 |
MAPT | Supranuclear palsy (OMIM: 601104) Dementia, frontotemporal (OMIM: 600274) Dementia (OMIM: 600,274) Supranuclear palsy, progressive atypical (OMIM: 260,540), Pick disease (OMIM: 172,700), Parkinson disease (OMIM: 168,600), tauopathy and respiratory failure (OMIM: 157,140), amyotrophic lateral sclerosis (OMIM: 105,400) Frontotemporal dementia (OMIM: 600274) | P10636 |
PSEN1 | Frontotemporal dementia (OMIM: 600274) Disease (OMIM: 172700) Amyotrophic lateral sclerosis (OMIM: 105400) Alzheimer disease (OMIM: 104300) Cardiomyopathy dilated 1U (OMIM: 613694) Acne inversa (OMIM: 613737) Frontotemporal dementia (OMIM: 600274) | P49768 |
TARDBP | Amyotrophic lateral sclerosis (OMIM: 105400) Frontotemporal dementia (OMIM: 600274) Frontotemporal dementia (OMIM: 600274) | Q13148 |
VCP | Frontotemporal dementia (OMIM: 600274) Amyotrophic lateral sclerosis (OMIM: 105400) | P55072 |