Fig. 1

Diagrammatic representation of the HEV largest non-structural polyprotein (ORF1) showing the Y-domain of HEV. The HEV ORF1 constitutes seven domains which include MTase: methyltransferase; Y: Y; PCP: papain-like cysteine protease; P/HVR: proline-rich/hypervariable region; X: macro; Hel/NTPase: helicase/nucleotide triphosphatase; and RdRp: RNA-dependent RNA polymerase. The Y-domain (AF444002) constitutes 228 amino acids and comprises a potential palmitoylation-site (C₃₃₆C₃₃₇) and an alpha-helical motif (L₄₁₀Y₄₁₁S₄₁₂W₄₁₃L₄₁₄F₄₁₅E₄₁₆)