Fig. 2
From: Pathophysiological effects of Tamiflu on liver and kidneys of male rats
A–D Photomicrographs of liver sections of G2 stained with H&E. A shows areas of faintly stained autolysed hepatocytes (*). The blood sinusoids and the CV are congested with blood. (X100). B displays swollen and basophilic-stained hepatocytes. The hepatocytes exhibit pleomorphic nuclei. The nuclei are either pyknotic or vanished. (X1000). C shows a dilated branch of the portal vein (PoV) which exhibits a deformed and ruptured endothelial lining. The tissue architecture is disrupted. Notice the autolysed narrow area of the tissue underneath the endothelial lining of the vein. The cytoplasm of the hepatocytes is coagulated and vacuolated. Also, the hepatocytes’ nuclei are shrunken. (X100). D shows an enlarged area nearby a CV (at the bottom of the figure). The hepatocytes show coagulative necrosis (*). Also, a Langhans giant cell (LGC) invades the area; it presumably scavenges the degenerated cells. (X1000)