Phyto-factories of anti-cancer compounds: a tissue culture perspective

Patel, Poonam; Patel, Vaibhav; Modi, Arpan; Kumar, Sushil; Shukla, Yogesh M.

doi:10.1186/s43088-022-00203-5

Beni-Suef University Journal of Basic and Applied Sciences

Table 4 Potential bioactive compounds targeted with anticancer properties in plants

From: Phyto-factories of anti-cancer compounds: a tissue culture perspective

Plant species	Common name	Active compound	Explant	Cancer cell lines	References
Carica Papaya	Papaya	Polyphenols	Seeds	Prostate cancer (PC-3) Cell line	[10]
Carica Papaya	Papaya	Polyphenols	Aqueous leaf extract	Breast Cancer Cells MCF-7	[115]
Smilax China	Madhusnuhi	Kandelin B-5 (1)	Rhizome	Acute monocytic leukemia (THP-1) cells	[113]
Achyranthes aspera	Devil’s horsewhip/ Prickly Chaff flower	Steroidal saponins, phenolic acids, alkaloids,	Root extract	Liver (Hep-2) & colon (HT-29) cell line	[95]
Syzygium aromaticum	Clove	Eugenin	Dried buds powdered cloves extract	HT-29 colon cancer cells	[60]
Citrus Peel	–	Polymethoxy-flavones	Juice	Blocks the metastasis cascade, inhibit cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis	[107]
Cinnamomum burmannii	Cinnamon	Cinnamic acid	Cisplatin and Cinnamon essential oil	HeLa cells	[58]
Cinnamomum burmannii	Cinnamon	Trans-cinnamaldehyde	Cinnamon Oil	MDA-MB-231 breast cancer cell line	[100]
Mangifera indica L	Mango	Antioxidants	Kernal	Human breast cancer (MCF-7 and MDA-MB-231 cell lines	[1]
Metha spp. (Mentha arvensis, M. longifolia, M. spicata and M. viridis)	Mint	Phenols and flavonoids	Whole plant extract	A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate cell lines	[92]
Mentha longifolia			Leaves extract	HepG2 and Vero mammalian cell lines	[6]
Zingiber officinale	Ginger	Quercitin	Leaves	HCT116, SW480 and LoVo human colorectal cell lines	[74]
Zingiber officinale	Ginger	Quercitin	Rhizome	human cervical cancer HeLa cells and breast cancer MDA-MB-231 cell	[14]
Ficus carica	Fig	Flavonoids and polyphenols	Fruit	MCF 7 breast cancer cell lines	[46]
Cinnamomum verum	Cinnamon	Cinnamic acid	Essential oil	(FaDu, Detroit-562 and SCC-25) head and neck carcinoma cells	[110]
Moringa oleifera	Drum sticks	Eugenol, isopropyl isothiocynate, D-allose, and hexadeconoic acid ethyl ester	Leaves, bark and seed extract	MDA-MB-231 and HCT-8 Breast and colorectal cancer cell lines	[8]
Colochirus anceps	Sea cucumber	Triterpene glycosides		Human leukemia and colorectal cancer cells	[13]
Coffea Arabica and coffee robusta	Coffee	Caffeine, Chlorogenic acid, caffeic acid	Coffee beans extract	HeLa and PA-1 cell lines	[82]
Coffea arabica				HT‐29 (colon) and SCC‐25 (oral) cancer cell lines	[69]
Hypericum perforatum	St Johns Wort	Hypericin	Aerial part	MCF-7 breast cancer cell line	[64]
Morus nigra	Mulberry	Resveratrol (stillbene –polyphenol)	Fruit extract	Breast cancer cell line (MCF 7)	[4]
Argemone mexicana L	Prickly poppy	Beberine	Stem and leaves	A549, SiHa and KB Cell lines	[70]
Taraxacum	Dandelion	Flavonoid	Root extract	HT-29 colorectal cell line	[73]
Glycine max	Soybean	Isoflavones and saponins (Daidzein)	Seeds	HT29 colon cancer cell line	[59]
Origanum vulgare L	Oregano	Carvacrol and thymol	Aerial part	Hepatocarcinoma HepG2 cancer cell line	[33]
Piper nigrum	Black pepper	Piperine	Seeds	Colorectal carcinoma cell lines (HCT-116, HCT-15, and HT-29)	[78]
Capsaic annum L	Red chilli	Capsaicin	Fruit	HepG2 hepatocellular cancer cells	[5]
Gossypium barbadense L	Cotton	Phenolics	Leaves	Bone Cord Cells	[72]
Annona muricata L	Custard apple	Annonacin	Leaf extract	MCF-7 cell	[86]
Avena sativa	Oat	β-glucan	oats β-glucan	Me45 melanoma cell line	[25]
Curcuma longa	Turmeric	Curcumin	Tuber	Her2 breast cancer cell lines	[61]
Daphne striata Tratt	-	Mezerein	Aerial parts	MCF-7, A549, LNCaP, ACHN, and C32	[103]
D. mezereum L
Camellia Sinensis	Tea	Flavonoids and polyphenol	Young leaves	Caco-2, colon carcinoma cells	[35]
Vitis venifera	Grapes	Oligomeric proanthocyanidins	seed extract	H716 colorectal cancer cells	[83]
Allium cepa	Onion	Flavonoids (Fisetin)	Onion bulb	MDA-MB-231 breast cancer cell line	[38]
Rubus idaeus L	Wild Raspberry	Flavonoids and phenolics	Leaf extract	HCT-116 colorectal cell line	[106]
Matricaria recutita L	Chamomile	terpenoids α-bisabolol, flavonoids	Flowers	HepG2 Human hepatoma cells	[9]
Olea europaea	Olive	oleuropein	Oil	143B, Osteosarcoma Cells	[79]

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