Table 6 Genotype distribution and allelic frequency of TGF-β1 (+915G>C) in controls and patients with ovarian cancer
Cytokine gene | Control (N = 48) | Ovarian cancer (N = 48) | P value | OR (95% CI) | AAIC | BBIC |
|---|---|---|---|---|---|---|
TGF-β1 (+915G>C) Genotype (N, %) | ||||||
G/G | 41 (85.4%) | 31 (64.6%) | P < 0.05 | 1.00 | ||
G/C | 6 (12.5%) | 17 (35.4%) | P < 0.05 | 3.75 (1.32–10.61) | 131.4 | 136.5 |
C/C | 1 (2.1%) | 0 (0.0%) | NS | 0.976 (0.931–1.023) | ||
Dominant model (GC+CC vs. GG) GC+CC | 7 (14.6%) | 17 (35.4%) | P < 0.05 | 3.21 (1.19–8.70) | ||
Recessive model (CC vs. GG+GC) GG+GC | 47 (97.9%) | 48 (100%) | NS | 1.00 | ||
C/C | 1 (2.1%) | 0 (0.0%) | NS | 0.979 (0.940–1.020) | ||
Allele frequency (N, %) | ||||||
G | 88 (92.0%) | 79 (82.0%) | NS | 0.422 (0.173–1.032) | ||
C | 8 (8.0%) | 17 (18.0%) | NS | 2.367 (0.969–5.785) | ||