Table 3 Phenotypic and genotypic antibiotic resistance profile of Klebsiella pneumonia
*Strain code and its phenotypic antibiotic resistance profile | Genotypic resistance profile | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β-lacta-mases | Metallo-β-lactamases and/or Carbapen-emases | Amino-glycoside transferase | Quinolone targets’ protective proteins (Qnr) | Efflux pump | Porins mutation | Positive detected genes | Positive resistance category | Resistance category | |||||
blaCTX-M | blaTEM | blaVIM | blaNDM1 | blaKPC | Aada1 | qnrB | qnrS | acrAB | OmpK35 | ||||
K1 P, AMP, SAM, AMC, TZP, CL, CE, CTX, CEQ, ATM, OT, CLR, NOR, OFX, K, NV, S, AK | + | + | NA | NA | NA | − | − | − | + | − | 3 | 2 | β-lactams + Efflux pump + muted/deleted porin protein |
K2 P, AMP, SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, K, NV, S, N, AK | + | + | − | − | − | − | − | + | + | − | 4 | 3 | β-lactams + Efflux pump + Fluroquinolones + muted/deleted porin protein |
K3 P, AMP, SAM, AMC, TZP, CL, CE, CTX, CEQ, ATM, CLR, OT, C, NOR, OFX, ENR, K, NV, S, NO, AK | − | + | NA | NA | NA | − | − | − | + | − | 2 | 2 | β-lactams + Efflux pump + muted/deleted porin protein |
K4 P, AMP, SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | − | − | − | + | + | − | 4 | 3 | β-lactams + Efflux pump + Fluroquinolones + muted/deleted porin protein |
K5 AMP, SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | − | − | − | − | + | − | 3 | 2 | β-lactams + Efflux pump + muted/deleted porin protein |
K6 AMP, SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | + | − | − | + | + | − | 4 | 4 | β-lactams + Efflux pump + Carbapenem Fluroquinolones + muted/deleted porin protein |
K7 AMP, SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | − | − | − | + | + | − | 4 | 3 | β-lactams + Efflux pump + Fluroquinolones + muted/deleted porin protein |
K8 AMP, SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | + | + | − | + | + | − | 6 | 5 | β-lactamases + Carbapenemases + Aminoglycosides + Efflux pump + Fluroquinolones + muted/deleted porin protein |
K9 SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | − | − | − | + | + | − | 4 | 3 | β-lactamases + Efflux pump + Fluroquinolones + muted/deleted porin protein |
K10 SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | − | + | − | + | + | − | 5 | 4 | β-lactamases + Efflux pump + Aminoglycosides + Fluroquinolones + muted/deleted porin protein |
K11 SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | − | + | − | − | + | − | 4 | 3 | β-lactamases + Efflux pump + Aminoglycosides + muted/deleted porin protein |
K12 SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, LOM, ENR, NV, S, N, AK | + | + | − | − | − | + | − | + | + | − | 5 | 4 | β-lactamases + Aminoglycosides + Efflux pump + Fluroquinolones + muted/deleted porin protein |
K13 SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, ENR, NV, S, N | − | + | − | − | − | + | − | + | + | − | 4 | 4 | β-lactamases + Efflux pump + Aminoglycosides + Fluroquinolones + muted/deleted porin protein |
K14 SAM, AMC, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, ENR, NV, S, N | + | + | − | + | − | + | − | + | + | − | 6 | 5 | β-lactamases + Carbapenemases + Aminoglycosides + Efflux pump + Fluroquinolones + muted/deleted porin protein |
K15 SAM, TZP, CL, CE, CTX, CFP, CEQ, MEM, ATM, CLR, OT, C, NOR, OFX, ENR, NV, S, N | + | + | − | − | + | − | − | + | + | − | 5 | 4 | β-lactamases + Efflux pump + Carbapenemases + Fluroquinolones + muted/deleted porin protein |