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Table 1 Fractional factorial design for optimization of preparation of MNPs with results showing the selected experiment (run order 14)

From: Preparation and characterization of polymyxin B- and histidine-coupled magnetic nanoparticles for purification of biologics from acquired endotoxin contamination

Run order pH Temp Molarity of iron salts Dextran% Time Ammonia% z-average PdI pk1 area intensity%
1 11 60 2:1 20 15 28 51.26 0.467 91.3
2 9 60 2:1 20 60 28 89.71 0.302 93.8
3 11 85 2:1 50 60 28 54.16 0.376 52.5
4 11 85 1:1 20 15 28 82.66 0.643 83.1
5 11 85 1:1 50 15 7.5 104.8 0.371 91.7
6 10 72.5 1:1 35 37.5 17.75 117.6 0.249 100
7 11 60 1:1 50 60 28 70.22 0.27 97.1
8 11 60 2:1 50 15 7.5 92.38 0.26 100
9 10 72.5 2:1 35 37.5 17.75 81.87 0.264 100
10 9 85 2:1 20 15 7.5 89.53 0.308 100
11 9 60 1:1 50 15 28 104 0.229 99
12 9 60 1:1 20 15 7.5 90.15 0.358 85.1
13 9 85 1:1 20 60 28 99.7 0.401 98.8
14 9 85 2:1 50 15 28 59.04 0.275 98.2
15 11 85 2:1 20 60 7.5 493.4 0.533 58.7
16 11 60 1:1 20 60 7.5 115 0.205 100
17 9 85 1:1 50 60 7.5 96.06 0.28 98.8
18 9 60 2:1 50 60 7.5 65.74 0.257 95