Table 1 Substitution arrangement of 1,3-thiazine derivatives along with their NA inhibitory activities
S. No. | R1 | R2 | Inhibition rates (%) | Activity |
|---|---|---|---|---|
| Â |
| Â | Â | Â |
1 | 2-Cl-5-NO2 | Et | 39.94 | 0.1772 |
2 | 3-NO2 | Et | 16.21 | 0.7134 |
3 | 2-EtO | Et | 37.18 | 0.2278 |
4 | 2-MeO | Et | 68.08 | -0.3290 |
5 | 4-Cl | Et | 39.94 | 0.1772 |
6 | 3,4-diMeO | Et | 29.65 | 0.3752 |
7 | 4-NO2 | Et | 60.40 | -0.1833 |
8 | 4-N(Me)2 | Et | 19.86 | 0.6059 |
9 | 4-AcO | Et | 25.62 | 0.4629 |
10 | 4-F | Et | 37.04 | 0.2304 |
11 | 4-MeO | Et | 10.25 | 0.9423 |
12 | 4-Me | Et | 17.48 | 0.6740 |
13 | 3-Et-4AcO | Et | 23.49 | 0.5128 |
14 | 2-NO2 | t-Bu | 52.30 | -0.0400 |
15 | 3-NO2 | (CH2)2OCH3 | 59.81 | -0.1727 |
| Â |
| Â | Â | Â |
16 | 2-Cl-5-NO2 | Et | 34.37 | 0.2809 |
17 | 3-NO2 | Et | 9.79 | 0.9645 |
18 | 2-EtO | Et | 19.28 | 0.6219 |
19 | 2-MeO | Et | 23.78 | 0.5059 |
20 | 4-Cl | Et | 14.11 | 0.7844 |
21 | 3,4-diMeO | Et | 17.06 | 0.6868 |
22 | 4-N(Me)2 | Et | 21.22 | 0.5697 |
23 | 4-OH | Et | 23.93 | 0.5023 |
24 | 4-F | Et | 14.87 | 0.7578 |
25 | 4-MeO | Et | 13.36 | 0.8119 |
26 | 4-Me | Et | 8.03 | 1.0589 |
27 | 3-Et-4OH | Et | 25.47 | 0.4663 |
28 | 2-NO2 | t-Bu | 17.66 | 0.6686 |
29 | 3-NO3 | (CH2)2OCH3 | 11.98 | 0.8661 |
