Table 2 Drug-likeness based on Lipinski parameters and the number of rotatable bonds of the synthetic compounds
Compound | MW ≤ 750 | n donorHB | n accptHB | QPlogPo/w | n violations ≤ 1 | #n rotor |
|---|---|---|---|---|---|---|
NC1 | 284.311 | 0 | 3.25 | 3.781 | 0 | 7 |
NC6 | 314.337 | 0 | 4.00 | 3.871 | 0 | 8 |
NC7 | 282.338 | 0 | 2.50 | 4.410 | 0 | 7 |
NC5 | 326.391 | 0 | 3.25 | 4.538 | 0 | 8 |
NC2 | 363.207 | 0 | 3.25 | 4.365 | 0 | 7 |
NC8 | 269.256 | 0 | 2.75 | 2.786 | 0 | 6 |
NF2 | 284.311 | 0 | 4.00 | 3.293 | 0 | 2 |
NF4 | 312.365 | 0 | 4.00 | 3.988 | 0 | 3 |
NF5 | 326.391 | 0 | 4.00 | 4.314 | 0 | 3 |
NF7 | 269.256 | 0 | 3.75 | 2.337 | 0 | 1 |
NPC3 | 270.284 | 0 | 3.00 | 3.092 | 0 | 2 |
NPC5 | 300.310 | 0 | 4.00 | 3.154 | 0 | 3 |
NPC7 | 298.338 | 0 | 3.00 | 3.787 | 0 | 3 |
NPC6 | 312.365 | 0 | 3.00 | 4.115 | 0 | 3 |
NPC4 | 349.180 | 0 | 3.00 | 3.681 | 0 | 2 |
NPC8 | 315.282 | 0 | 4.00 | 2.348 | 0 | 3 |
NP4 | 256.257 | 1 | 3.00 | 2.382 | 0 | 2 |
NP5 | 286.284 | 1 | 4.00 | 2.494 | 0 | 3 |
NP6 | 298.338 | 1 | 3.00 | 3.361 | 0 | 3 |
NP9 | 284.311 | 1 | 3.00 | 3.040 | 0 | 3 |
NP7 | 335.153 | 1 | 3.00 | 2.949 | 0 | 2 |