Table 3 Comparison between patients with fibrosis and patients without fibrosis regarding patients’ characteristics
Characteristics | No fibrosis (no = 25) | Fibrosis (no = 28) | P value |
|---|---|---|---|
Age (mean ± SD) | 8.6 ± 1.5 | 13.7 ± 2.1 | < 0.001 |
Sex | 0.685 | ||
Males | 13 (52.0%) | 13 (46.4%) | |
Females | 12 (48.0%) | 15 (53.6%) | |
Consanguinity | 0.805 | ||
No | 18 (72.0%) | 21 (75.0%) | |
Yes | 7 (28.0%) | 7 (25.0%) | |
Family history | 0.442 | ||
No | 16 (64.0%) | 15 (53.6%) | |
Yes | 9 (36.0%) | 13 (46.4%) | |
BMI | 15.9 ± 2.1 | 15.5 ± 1.8 | 0.326 |
DM | > 0.999 | ||
No | 25 (100.0%) | 27 (96.4%) | |
Yes | 0 (0.0%) | 1 (3.6%) | |
Hb | 7.6 ± 1.2 | 7.1 ± 1 | 0.098 |
TLC | 7.3 ± 4.0 | 7.3 ± 3.4 | 0.976 |
PLT | 320.0 ± 97.7 | 256.9 ± 103.2 | 0.027 |
PT | 11.7 ± 0.5 | 12 ± 0.9 | 0.128 |
Albumin | 4.4 ± .46699 | 4.2 ± .59338 | 0.261 |
Bilirubin | 0.9 ± 0.3 | 0.9 ± 0.5 | 0.991 |
AST | 40.2 ± 15.9 | 74.3 ± 21.8 | < 0.001 |
ALT | 32.9 ± 12.6 | 57.7 ± 23.3 | < 0.001 |
Urea | 20.8 ± 8.6 | 24.2 ± 6.9 | 0.121 |
Creatinine | 0.5 ± 0.1 | 0.4 ± 0.2 | 0.836 |
Age at 1st blood transfusion (months) | 0.7 ± 0.5 | 0.6 ± 0.2 | 0.439 |
Frequency of blood transfusion (months) | 1 ± 0.1 | 0.8 ± 0.3 | 0.001 |
Hepatomegaly | < 0.001 | ||
Homogenous | 25 (100.0%) | 0 (0.0%) | |
Coarse | 0 (0.0%) | 28 (100.0%) | |
Spleen | 0.317 | ||
Splenectomy | 20 (80.0%) | 19 (67.9%) | |
Splenomegaly | 5 (20.0%) | 9 (32.1%) | |
HBsAg | 0.340 | ||
−ve | 25 (100.0%) | 27 (96.4%) | |
+ve | 0 (0.0%) | 1 (3.6%) | |
HCV Ab | 0.05 | ||
−ve | 25 (100.0%) | 23 (82.1%) | |
+ve | 0 (0.0%) | 5 (17.9%) | |
Chelating agents | < 0.001 | ||
Regular | 25 (100.0%) | 0 (0.0%) | |
Irregular | 0 (0.0%) | 28 (100.0%) |