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Table 5 Cox regression analysis for prediction of failure to treatment

From: Association of genetic polymorphism of NUDT15, TPMT and ITPA gene in the toxicity and efficacy of azathioprine-based regimen in Egyptian inflammatory bowel disease patients

 

Univariable

Multivariable

p

OR

95% CI

p

OR

95% CI

Age

0.668

0.995

0.973

1.018

    

Gender

0.605

1.140

0.694

1.871

    

Smoking

0.152

0.403

0.162

1.007

    

BMI

0.043

1.075

1.002

1.153

0.286

1.042

0.966

1.124

Comorbidities

0.037

1.645

1.167

2.798

0.053

1.702

0.993

2.918

Initial TLC

0.638

1.023

0.930

1.127

    

Initial ANC

0.696

0.977

0.868

1.099

    

Initial ALC

0.317

0.898

0.728

1.108

    

Initial platelets

0.982

1.022

0.997

1.067

    

Fecal Calprotectin

0.409

1.074

0.989

1.132

    

Association of AZA with steroids

 < 0.001

3.633

2.019

6.539

 < 0.001

3.402

1.877

6.166

rs1127354

0.517

1.402

0.504

3.898

    

rs1800460

0.009

4.879

1.490

15.976

0.019

4.214

1.270

13.981

  1. OR odds ratio; CI confidence interval
  2. Bold values indicate significant results < 0.05