Table 1 Approved monoclonal antibodies IFX, ADA, UST, VDZ and golimumab in IBD therapy; IL, interleukin; IV, intravenous; SC, subcutaneous [58]
From: A review article of inflammatory bowel disease treatment and pharmacogenomics
Biologic treatments | Trade name | Route | Approved use | Mechanism |
|---|---|---|---|---|
Infliximab | Remicade Remsima inflectra | IV | CD and UC | TNF antagonist |
Adalimumab | Humira | IV | CD and UC | TNF antagonist |
Golimumab | Simponi | SC | UC | TNF antagonist |
Ustekinumab | Stelara | IV induction SC maintenance | CD | Anti-Il-12 $ 23 |
Vedolizumab | Entyvio | IV | CD&UC | Anti-integrin |