Table 1 Composition of artemether and lumefantrine loaded LSES
i. Formulation code | A1:0.5 | B1:0.5 | C1:0.5 | A3:1 | B3:1 | C3:1 |
|---|---|---|---|---|---|---|
O:S:C | 23:51:26 | 16:56:28 | 15:57:28 | 23:58:29 | 16:63:21 | 11:66:23 |
Palm kernel oil (mg) | 187.44 | 129.44 | 120.24 | 185.04 | 123.52 | 68.32 |
Solutol: Tween 80 (mg) | 204.2: 204.2 | 223.52: 223.52 | 226.6: 226.6 | 230.6: 230.6 | 253.68: 253.68 | 274.36: 274.36 |
Capryol pgmc (mg) | 204.16 | 223.52 | 226.56 | 153.76 | 169.12 | 182.96 |
Artemether (mg) | 80 | 80 | 80 | 80 | 80 | 80 |
ii. Formulation code | A3:1 | B3:1 | C3:1 | A3:2 | A1:0.5 | B1:0.5 |
|---|---|---|---|---|---|---|
O:S:C | 32:49:19 | 39:45:17 | 24:57:19 | 31:41:23 | 30:47:23 | 22:52:26 |
Oleic acid (mg) | 298.4 | 361.6 | 241 | 308.1 | 298.3 | 215.9 |
Solutol (mg) | 526.4 | 478.8 | 569.25 | 415.14 | 407.8 | 522.7 |
Capryol pgmc (mg) | 175.4 | 159.6 | 189.75 | 276.76 | 233.9 | 261.4 |
Lumefantrine (mg) | 50 | 50 | 50 | 50 | 50 | 50 |