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Table 4 Properties of artemether and lumefantrine LSES granules

From: Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Artemether formulation

A1:0.5

B1:0.5

C1:0.5

A3:1

B3:1

C3:1

B.D (g/cm3)

0.61 ± 0.02

0.57 ± 0.01

0.58 ± 0.01

0.58 ± 0.01

0.56 ± 0.01

0.55 ± 0

T.D (g/cm3)

0.81 ± 0.02

0.79 ± 0.02

0.76 ± 0

0.76 ± 0

0.72 ± 0.02

0.74 ± 0.02

C.I (%)

25.30 ± 2.0

26.91 ± 2.56

23.61 ± 1.40

23.15 ± 1.6

22.04 ± 3.6

25.29 ± 2.0

H. Q

1.34 ± 0.04

1.37 ± 0.05

1.31 ± 0.02

1.30 ± 0.02

1.29 ± 0.06

1.34 ± 0.03

A.R (°)

20.62 ± 2.05

16.48 ± 0.50

21.80 ± 1.0

17.82 ± 0.25

18.35 ± 1.34

19.19 ± 3.03

F.R (g/s)

7.68 ± 0.45

5.89 ± 0.83

7.58 ± 0.84

7.05 ± 1.39

8.55 ± 0.25

8.07 ± 0.30

Lumefantrine formulations

A3:1

A1:0.5

C3:1

   

Lumefantrine LSES granules

B.D (g/cm3)

0.60 ± 0.03

0.60 ± 0.03

0.58 ± 0.01

   

T.D (g/cm3)

0.73 ± 0.04

0.75 ± 0.02

0.74 ± 0.02

   

C.I (%)

17.49 ± 1.45

19.41 ± 4.99

21.65 ± 3.25

   

H.Q

1.21 ± 0.03

1.25 ± 0.07

1.28 ± 0.05

   

A.R (°)

18.34 ± 0.62

23.2 ± 0.98

23.75 ± 1.18

   

F.R (g/s)

7.40 ± 0.21

7.37 ± 0.29

7.43 ± 0.14

   
  1. Each data is expressed as mean ± SD; n = 3
  2. B.D bulk density, T.D tapped density, C.I compressibility index, H.Q Hausner’s quotient, A.R angle of repose, F.R flow rate