Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Beni-Suef University Journal of Basic and Applied Sciences

Table 5 Release kinetics studies

Batches	Dissolution technique/media	Zero order R²	First order R²	Higuchi R²	Krosmeyers Peppas R²	Krosmeyers Peppas n
C 3:1	Rotating basket (SGF pH 1.2)	0.387	0.671	0.876	0.975	0.239
C 3:1	Rotating basket (phosphate buffer pH 6.8)	0.437	0.738	0.890	0.944	0.312
A 1:0.5	Dialysis membrane (SGF pH 1.2)	0.742	0.899	0.948	0.949	0.479
C 1:0.5	Dialysis membrane (SGF pH 1.2)	0.955	0.886	0.789	0.949	0.479
B 1: 0.5	Dialysis membrane (phosphate buffer pH 6.8)	0.965	0.886	0.789	0.949	0.479
A 3: 1	Dialysis membrane (phosphate buffer pH 6.8)	0.917	0.977	0.981	0.949	0.479