Table 5 ADMET properties of newly designed compounds
S.No. | Compound code | Mol weight | Log P | HBD | HBA | Lipinski rule | Hepatotoxicity | Carcinogenicity |
|---|---|---|---|---|---|---|---|---|
1 | THN_RD1 | 471.61 | 4.63 | 1 | 3 | Nil | inactive | inactive |
2 | THN_RD2 | 483.64 | 4.68 | 1 | 3 | Nil | inactive | inactive |
3 | THN_RD3 | 459.56 | 4.57 | 1 | 4 | Nil | active | inactive |
4 | THN_RD4 | 459.56 | 4.41 | 1 | 4 | Nil | inactive | inactive |
5 | THN_RD5 | 459.56 | 4.31 | 1 | 4 | Nil | inactive | inactive |
6 | THN_RD6 | 471.59 | 4.26 | 2 | 4 | Nil | active | inactive |
7 | THN_RD7 | 492.01 | 4.24 | 2 | 4 | Nil | active | inactive |
8 | THN_RD8 | 465.98 | 4.41 | 1 | 5 | Nil | active | inactive |
9 | THN_RD9 | 489.63 | 4.16 | 1 | 4 | Nil | inactive | inactive |
10 | THN_RD10 | 458.57 | 3.93 | 1 | 4 | Nil | inactive | inactive |