Anti-Alzheimer potential of Solanum lycopersicum seeds: in vitro, in vivo, metabolomic, and computational investigations

Beni-Suef University Journal of Basic and Applied Sciences

Table 7 Effect of SLSE on IL-6, glycated end product, and BDNF levels in rats with Alzheimer disease

	BDNF (Pg/g tissue)	Glycated end product (μg/g tissue)	IL-6 (Pg/mL)
Control	343.0 ± 10.20^a	12.7 ± 1.20^a	39.6 ± 3.00^a
AlCl₃-AD % change	167.0 ± 10.90^b -50.3%	40.8 ± 3.10^b 221.2%	130.0 ± 8.00^b 227.7%
AD crude extract % improvement	230.0 ± 3.50^c 18.3%	26.0 ± 2.50^c 116.6	66.5 ± 4.00^c 160.1
Donepezil drug % improvement	288.0 ± 16.00^e 35.2	12.9 ± 1.10^a 219.6	39.0 ± 2.80^a 229.4

Data are presented as mean ± SD (n = 10). The groups that share an identical letter do not differ considerably. Conversely, those that have various letters are, at p ≤ 0.05. \(\% {\text{change}} = \frac{{{\text{mean}}\;{\text{ of}}\;{\text{ negative }}\;{\text{control}} - {\text{mean }}\;{\text{of}}\;{\text{ treatment }}\;{\text{group}}}}{{{\text{mean }}\;{\text{of }}\;{\text{negative }}\;{\text{control}}}} \times 100\), \(\% {\text{improvment}} = \frac{{{\text{mean }}\;{\text{of }}\;{\text{positive }}\;{\text{control}} - {\text{mean }}\;{\text{of }}\;{\text{treatment}}\;{\text{ group}}}}{{{\text{mean }}\;{\text{of }}\;{\text{negative }}\;{\text{control}}}} \times 100\)