Anti-Alzheimer potential of Solanum lycopersicum seeds: in vitro, in vivo, metabolomic, and computational investigations

Beni-Suef University Journal of Basic and Applied Sciences

Table 8 Effect of SLSE on TAC, MDA, and GSH levels in rats with induced Alzheimer disease

	Control rats	Intoxicated rats	Crude extract	Standard drug
TAC (mM/L) % change % improvement	0.8 ± 0.3^a –	0.2 ± 0.2^d − 74.1	0.5 ± 0.5^c 38.2	0.7 ± 0.2^b 52.8
MDA (nmol/g tissue) % change % improvement	26.1 ± 2.1^d	144.0 ± 6.1^a + 451.7	55.1 ± 3.0^c 340.4	41.1 ± 2.5^b 394.2
GSH (tissue) (mg/g tissue) % change % improvement	25.0 ± 1.0^a	9.7 ± 3.0^d 60.9	17.3 ± 1.1^c 30.1	23.1 ± 2.2^b 53.4

Data are presented as mean ± SD (n = 10). The groups that share an identical letter do not differ considerably. Conversely, those that have various letters are, at p ≤ 0.05. \(\% {\text{change}} = \frac{{{\text{mean}}\;{\text{ of }}\;{\text{negative }}\;{\text{control}} - {\text{mean }}\;{\text{of }}\;{\text{treatment }}\;{\text{group}}}}{{{\text{mean}}\;{\text{of }}\;{\text{negative }}\;{\text{control}}}} \times 100\), \(\% {\text{improvment}} = \frac{{{\text{mean }}\;{\text{of}}\;{\text{ positive }}\;{\text{control}} - {\text{mean }}\;{\text{of}}\;{\text{ treatment}}\;{\text{ group}}}}{{{\text{mean}}\;{\text{ of }}\;{\text{negative}}\;{\text{ control}}}} \times 100\)