Fabrication and evaluation of smart pH/thermo dual-responsive injectable intratumoral in situ depot hydrogels for controlled 5-FU delivery

Beni-Suef University Journal of Basic and Applied Sciences

Table 3 Drug release kinetics from in situ hydrogels at 25 °C

Codes	pH	Zero model		First model		Higuchi model		Korsmeyer–Peppas model
Codes	pH	K_o (h⁻¹)	R²	K₁ (h⁻¹)	R²	K₂ (h⁻¹)	R²	n	R²
IPLVCS-2	2.1	5.693	0.997	0.101	0.974	22.87	0.970	0.728	0.988
IPLVCS-2	7.4	2.976	0.998	0.037	0.995	11.94	0.968	0.712	0.992
IPLVCS -5	2.1	4.123	0.999	0.057	0.989	16.48	0.962	0.852	0.993
IPLVCS -5	7.4	3.657	0.996	0.048	0.979	14.44	0.934	0.846	0.987
IPLVCS -6	2.1	3.549	0.999	0.046	0.992	14.14	0.955	0.837	0.995
IPLVCS -6	7.4	3.085	0.996	0.038	0.988	12.29	0.952	0.841	0.990