Fabrication and evaluation of smart pH/thermo dual-responsive injectable intratumoral in situ depot hydrogels for controlled 5-FU delivery

Beni-Suef University Journal of Basic and Applied Sciences

Table 4 Drug release kinetics at 37 °C

Sample codes	pH	Zero order		First order		Higuchi model		Korsmeyer–Peppas model
Sample codes	pH	K_o (h⁻¹)	R²	K₁ (h⁻¹)	R²	K₂ (h⁻¹)	R²	n	R²
IPLVCS-2	2.1	3.591	0.994	0.047	0.997	14.53	0.981	0.888	0.975
IPLVCS-2	7.4	2.618	0.998	0.031	0.991	10.36	0.943	0.902	0.925
IPLVCS -5	2.1	3.664	0.997	0.047	0.986	14.56	0.949	0.995	0.980
IPLVCS -5	7.4	3.331	0.994	0.042	0.981	13.23	0.945	0.908	0.977
IPLVCS -6	2.1	3.177	0.998	0.040	0.996	12.74	0.967	0.912	0.947
IPLVCS -6	7.4	2.673	0.996	0.034	0.997	10.73	0.968	0.869	0.977