Phenolic-rich fraction of green tea attenuates histamine-mediated cardiopulmonary toxicity by inhibiting Cox-2/NF-κB signaling pathway and regulating oxidant/antioxidant balance

Beni-Suef University Journal of Basic and Applied Sciences

Table 3 Pulmonary lesion scoring in different treatment groups

	Control	100 PRFGT	200 PRFGT	HIS	HIS + 100 PRFGT	HIS + 200 PRFGT
Bronchial and bronchiolar lesions
Epithelial degeneration and necrosis	0^a	0^a	0^a	2^b	0^a	0^a
Luminal inflammation	0^a	0^a	0^a	4^b	0^a	0^a
Vascular lesions
Congestion	0^a	0^a	0^a	4^b	1^c	0^a
Perivascular inflammation	0^a	0^a	0^a	2^b	1^c	0^a
Interstitial lesions
Inflammation	0^a	0^a	0^a	4^b	2^c	0^a
Hemorrhage	0^a	0^a	0^a	3^b	2^c	0^a
Alveolar lesions
Collapse	0^a	0^a	0^a	3^b	1^c	0^a
Damage	0^a	0^a	0^a	3^b	1^c	0^a
Hemorrhage	0^a	0^a	0^a	3^b	2^c	0^a
Widening of alveolar septa	0^a	0^a	0^a	4^b	2^c	0^a

Data were signified as median (n = 25 microscopic fields). Various superscript letters (a, b, c, etc.) indicate a significant difference between groups at P ≤ 0.05