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Beni-Suef University Journal of Basic and Applied Sciences

Table 2 The acquired antibiotic resistance mechanisms in K. pneumoniae

From: Overcoming Klebsiella pneumoniae antibiotic resistance: new insights into mechanisms and drug discovery

Target gene

Antibiotic class

References

blaSHV, blaTEM, blaCTX, blaKLUC-5, blaSFO, blaGES, blaPER, blaVEB, blaTLA, blaKPC blaNDM, blaVIM, bla IMP, blaOXA, blaCMY, blaDHA, blaFOX, and blaMOX

β-lactam

[8, 32, 33, 40, 41]

aac, aph, ant, AcrAB-TolC, kpnEF, and KpnO

  

AcrAB-TolC, OqxAB, RarA, RamA, RamR, AcrR, rpsJ, 16S rRNA methylase, and tetA

Tigecycline

[7]

DNA gyrase, topoisomerase IV, mpK36, acrAB, kdeA, OqxAB, and aa(6’)-Ib-cr

Quinolone

[7]

phoPQ, pmrA, pmrD, mcr-1, and mgrB

Polymyxin

[7]

fos

Fosfomycin

[7]

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