Clinical and biological significance of microRNA-127 and microRNA-138 expression in women with breast cancer: response to treatment and survival impact

Beni-Suef University Journal of Basic and Applied Sciences

Table 2 Relation between miRNA-138, miRNA-127 and different parameters in cases group

	N = 75	miRNA 138	Test of Sig	p	miRNA 127	Test of Sig	p
	N = 75	Median	Test of Sig	p	Median	Test of Sig	p
Metastasis Status
No	54	13.27	U = 335.0^*	0.006^*	12.52	U = 366.50^*	0.018^*
Yes	21	6.35	U = 335.0^*	0.006^*	6.80	U = 366.50^*	0.018^*
Grade
Grade I	1					U = 102.0^*	0.043^*
Grade II	68	12.78	U = 86.0^*	0.019^*	12.06
Grade III	6	2.20			5.58
PT status
T1	9	15.45	H = 3.062	0.382	13.90	H = 5.281	0.152
T2	36	12.43			9.71
T3	23	8.26			8.26
T4	7	11.31			15.28
PN status
N0	15	14.38	H = 12.858^*	0.005^*	14.60	H = 8.702^*	0.034^*
N1	29	12.18			12.07
N2	17	16.76			6.72
N3	14	6.32			9.81
ER
No	31	13.50	U = 677.50	0.961	6.27	U = 360.50^*	0.001^*
Yes	44	12.10	U = 677.50	0.961	12.90	U = 360.50^*	0.001^*
PR
No	33	11.76	U = 649.50	0.642	6.35	U = 390.50^*	0.001^*
Yes	42	12.43	U = 649.50	0.642	12.90	U = 390.50^*	0.001^*
HER2/neu
Negative	59	12.18	U = 444.50	0.722	11.89	U = 395.0	0.319
Positive	16	12.33	U = 444.50	0.722	7.62	U = 395.0	0.319
Ki 67
Not done	14	13.20	H = 2.972	0.226	6.67	H = 11.792^*	0.003^*
Low (< 14)	16	13.79			15.37
High (equal or > 14)	45	11.78			8.26
Molecular subtype
Basal (Triple negative)	25	8.26	H = 5.252	0.154	5.89	H = 15.025^*	0.002^*
HER2/neu overexpressed	6	15.08			6.31
Luminal A	13	12.89			15.45
Luminal B	31	11.89			12.07
Toxicity grade
No	56	13.42	H = 5.252	0.154	12.08	H = 10.886^*	0.012^*
Grade 1	7	4.11			7.29
Grade 2	4	5.84			9.81
Grade 3	8	2.29			2.71
Progression status
No	50	12.78	U = 479.0	0.101	12.52	U = 352.0^*	0.002^*
Yes	25	8.20	U = 479.0	0.101	5.92	U = 352.0^*	0.002^*
Living Status
Dead	10	1.73	U = 126.50^*	0.002^*	2.33	U = 140.0^*	0.004^*
Alive	65	12.89	U = 126.50^*	0.002^*	12.05	U = 140.0^*	0.004^*

SD: Standard deviation U: Mann Whitney test H: H for Kruska–Wallis test
p: p-value for comparison between the studied categories *: Statistically significant at p ≤ 0.05
^#: Excluded from the comparison due to small number of cases (n = 1)