Table 4 COX regression analysis for the factors influencing relapse in the cases group using both single- and multiple-variables
Univariate | #Multivariate | |||
|---|---|---|---|---|
P | HR (LL – UL 95%C.I) | p | HR (LL–UL 95%C.I) | |
Age (years) | 0.653 | 0.991(0.953–1.030) | ||
Menstrual status (Postmenopausal) | 0.853 | 1.077(0.489–2.374) | ||
Family history | 0.350 | 0.044(0.0–30.685) | ||
Tumor side (left) | 0.156 | 0.564(0.256–1.243) | ||
Pathological subtype (IDC) | 0.605 | 0.754(0.259–2.198) | ||
Pathological stage (≥ 3) | 0.095 | 2.105(0.878–5.048) | ||
Metastasis Status | < 0.001* | 5.633(2.509–12.650) | 0.909 | 0.948(0.383–2.351) |
Grade (III) | 0.373 | 1.731(0.518–5.787) | ||
PT status (≥ 3) | 0.020* | 2.590(1.163–5.772) | 0.769 | 1.160(0.432–3.116) |
PN status (≥ 3) | 0.005* | 3.244(1.426–7.379) | 0.798 | 0.881(0.334–2.323) |
ER | 0.664 | 0.839(0.381–1.850) | ||
PR | 0.916 | 0.958(0.435–2.112) | ||
HER2/neu | 0.818 | 0.891(0.334–2.375) | ||
Ki 67 | 0.867 | 0.920(0.345–2.451) | ||
Molecular subtype (Tripple negative) | 0.138 | 1.818(0.825–4.010) | ||
CEA value | < 0.001* | 1.020(1.011–1.030) | 0.014* | 1.015(1.0–1.028) |
CA15.3.value | < 0.001* | 1.013(1.009–1.018) | 0.004* | 1.010(1.0–1.016) |
Chemotherapy status | 0.796 | 1.138(0.427–3.034) | ||
Chemo toxicity | 0.105 | 1.916(0.874–4.202) | ||
Toxicity grade | 0.215 | 1.643(0.749–3.603) | ||
Hormonal ttt | 0.446 | 0.737(0.336–1.616) | ||
Biological treatment | 0.885 | 0.915(0.274–3.057) | ||
miRNA 138 | 0.033* | 0.923(0.858–0.993) | 0.059 | 0.934(0.870–1.0) |
miRNA 127 | 0.004* | 0.893(0.828–0.964) | 0.098 | 0.931(0.855–1.013) |