Robust congregation influences of AB-PINACA and MDMB-4en-PINACA inhalation on neurobehavioral and cardiac disorders in mice

Beni-Suef University Journal of Basic and Applied Sciences

Table 4 Semi-quantitative histopathological scoring of all alterations appeared microscopically in cardiac and brain tissues of herbal used mice compared with control group by staining sections with H&E X100

Organs and lesions	Control	AB-PINACA	MDMB-4en-PINACA
Brain
Vascular congestion	−	++	+++
Neuronal degeneration	−	++	+++
Chromatolysis	−	++	+
Spongiosis	−	+	++
Gliosis	−	−	+
Heart
Congestion	−	+++	+++
Edema	−	++	++/+++
Myocytic degeneration	−	++	+++
Vacuolation	−	++	++
Infarction	−	+	++
Thrombosis	−	+	++

Absence of lesions (−), minimal degree (−/+), mild degree (+), moderate degree (++) and sever degree (+++)