The cytotoxicity effect and identification of bioactive compounds of Prismatomeris glabra crude leaf extracts against breast cancer cells

Zulkipli, Ninie Nadia; Rahman, Sholehah Ab; Taib, Wan Rohani Wan; Razali, Razifah Mohd; Ismail, Illyana; Ahmad, Wan Amir Nizam Wan; Daud, Che Ku Dahlan Che Ku

doi:10.1186/s43088-024-00490-0

Beni-Suef University Journal of Basic and Applied Sciences

Table 2 Detected compounds in LE, LM, and LW extracts

From: The cytotoxicity effect and identification of bioactive compounds of Prismatomeris glabra crude leaf extracts against breast cancer cells

Compound	Formula	Start	RT	End	m/z	Mass (DB)	Score (DB)	Diff (DB, ppm)
Ethanol extract (LE)
Tetracenomycin	C20 H16 O8	9.16	9.23	9.35	385.09	384.08	98.58	0.86
Silymarin	C25 H22 O10	10.83	10.96	11.04	483.13	482.12	98.91	0.97
Biochanin A Diacetate	C20 H16 O7	10.96	11.06	11.22	369.10	368.09	96.63	− 1.19
4-O-Caffeoyl-3-O-feruloylquinic acid	C26 H26 O12	10.98	11.06	11.23	531.15	530.14	97.88	− 1.49
Epigallocatechin 5,3′,5′-trimethyl ether 3-O-gallate	C25 H24 O11	11.78	11.83	11.94	501.14	500.13	98.19	0.97
Scutellarein 4′-methyl ether 7-(2″,6″-diacetylalloside)	C26 H26 O13	12.79	12.86	13.04	547.14	546.13	99.24	0.07
Quillaic acid	C30 H46 O5	14.00	14.07	14.21	487.34	486.33	98.18	0.8
Tomentosic acid	C30 H48 O6	14.02	14.07	14.18	505.35	504.35	98.99	0.99
Ganoderic acid DM	C30 H44 O4	14.02	14.08	14.26	469.33	468.32	98.49	1.14
Eplerenone	C24 H30 O6	23.65	23.76	23.92	415.21	414.20	99.18	− 0.22
1α,25-dihydroxy-26,27-dimethyl-20,21,22,22,23,23-hexadehydro-24a-homovitamin D3/1α,25-dihydroxy-26,27-dimethyl-20,21,22,22,23,23-hexadehydro-24a-homocholecalciferol	C30 H44 O3	24.36	24.43	24.55	453.34	452.33	97.12	− 1
Demethylphylloquinone	C30 H44 O2	27.12	27.24	27.30	437.34	436.33	98.99	− 0.62
Bryononic acid	C30 H46 O3	27.14	27.24	27.30	455.35	454.35	98.68	− 0.04
Lucidumol A	C30 H48 O4	27.17	27.24	27.31	495.34	472.36	99.39	0.39
Emmotin A	C16 H22 O4	29.69	29.82	29.94	301.14	278.15	99.52	− 1.03
Ganoderol A	C30 H46 O2	34.13	34.32	34.52	439.36	438.35	99.52	− 0.41
Betulinic acid	C30 H48 O3	34.18	34.32	34.61	457.37	456.36	99.25	0.3
Dehydroconicasterol	C29 H46 O	34.20	34.32	34.53	411.36	410.35	99.41	0.45
Methanol extract (LM)
Tetracenomycin	C20 H16 O8	9.21	9.27	9.41	385.09	384.09	98.42	− 1.68
Silymarin	C25 H22 O10	10.83	10.97	11.06	483.13	482.12	98.90	− 0.51
Biochanin A Diacetate	C20 H16 O7	11.34	11.41	11.59	369.10	368.09	99.56	− 0.01
Epigallocatechin 5,3′,5′-trimethyl ether 3-O-gallate	C25 H24 O11	11.78	11.83	11.97	501.14	500.13	99.19	0.91
Neoduleen	C18 H10 O5	12.79	12.85	12.98	307.06	306.05	96.17	− 3.58
Quillaic acid	C30 H46 O5	13.98	14.04	14.24	487.34	486.34	97.69	0.16
Tomentosic acid	C30 H48 O6	13.99	14.05	14.17	505.35	504.35	99.29	0.56
Sericoside	C36 H58 O11	13.98	14.05	14.21	684.43	666.40	95.00	0.14
Ganoderic acid DM	C30 H44 O4	13.98	14.05	14.25	469.33	468.32	98.61	0.19
Eplerenone	C24 H30 O6	23.63	23.74	23.90	415.21	414.20	99.22	− 0.97
Bryononic acid	C30 H46 O3	27.13	27.23	27.30	455.35	454.35	98.82	0.53
Demethylphylloquinone	C30 H44 O2	27.13	27.23	27.31	437.34	436.33	99.64	0.22
Ganoderol A	C30 H46 O2	34.13	34.32	34.76	439.36	438.35	99.01	− 0.40
Betulinic acid	C30 H48 O3	34.19	34.32	34.53	457.37	456.36	99.19	0.72
Dehydroconicasterol	C29 H46 O	34.21	34.32	34.47	411.36	410.36	99.18	0.78
Aqueous extract (LW)
Silymarin	C25 H22 O10	10.84	10.91	10.99	483.13	482.12	97.38	− 0.99
Epigallocatechin 5,3′,5′-trimethyl ether 3-O-gallate	C25 H24 O11	11.73	11.79	11.94	501.14	500.13	98.90	0.40
Scutellarein 4′-methyl ether 7-(2″,6″-diacetylalloside)	C26 H26 O13	12.76	12.82	12.95	547.15	546.13	99.08	− 0.48
Quillaic acid	C30 H46 O5	13.99	14.04	14.17	487.34	486.34	98.35	1.51
Ganoderic acid DM	C30 H44 O4	13.99	14.05	14.19	469.33	468.32	99.21	0.98
Biochanin A Diacetate	C20 H16 O7	19.39	19.47	19.62	369.10	368.09	98.75	− 0.11

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