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Fig. 4 | Beni-Suef University Journal of Basic and Applied Sciences

Fig. 4

From: Molecular mechanisms and the vital roles of resistin, TLR 4, and NF-κB in treating type 2 diabetic complications

Fig. 4

Role of resistin, TLR4, and NF-κB signalings in developing insulin resistance. : Stimulation/release; : Restore/repair; : Pathway of insulin resistance; : Physiological signalings. : Stimulation; : Inhibition. FGF21: Fibroblast growth factor 21; FGFR fibroblast growth factor receptor gene, Akt protein kinase B, ERK extracellular signal-regulated kinases, MD2 myeloid differentiation factor 2, TLR4 Toll-like receptor 4, NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, Ik-B IκB kinase, mTORC1 Mammalian target of rapamycin complex 1, AMPK AMP-activated protein kinase, PI3K phosphatidylinositol-3-kinase, JAK c-Jun N-terminal kinases, MyD88 myeloid differentiation primary response 88, DR diabetic retinopathy, APPl1 adaptor protein, phosphotyrosine interacting, IR insulin resistance, α-MSH & CART α-melanocyte-stimulating hormone & cocaine and amphetamine-regulated transcript, AgRP & NPY Agouti-related protein & neuropeptide Y, GHSR growth hormone secretagogue receptor, POMC proopiomelanocortin, FA-O in SK.M, skeletal muscle lipid oxidation, SoCS3 suppressor of cytokine signaling 3, PTP1B protein tyrosine phosphatase 1B, ER endoplasmic reticulum

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