Annette B, Ramesh K, Hemachandra Reddy P (2017) Dynamics of diabetes and obesity: epidemiological perspective. Biochimica et Biophysica Acta. 1863:1026–1036
Article
CAS
Google Scholar
WHO (2020) Diabetes. Word health organization. https://www.who.int/news-room/fact-sheets/detail/diabetes
IDF (2020) Diabetes facts & figures. International Diabetes Federation. 9th edition. https://www.idf.org/aboutdiabetes/what-is-diabetes/facts-figures.html
Chang WC, Wu JSB, Chen CW, Kuo PL, Chien HM, Wang YT, Shen SC (2015) Protective effect of vanillic acid against hyperinsulinemia, hyperglycemia and hyperlipidemia via alleviating hepatic insulin resistance and inflammation in high-fat diet (HFD)-fed rats. Nutrients. 7(12):9946–9959
Article
CAS
Google Scholar
Kristina B, Fran Stjepan N, Ivan K, Ivana PR (2018) Treatment approach to type 2 diabetes: Past, present and future. World J Diabetes. 15: 9(12):209–219
Yang-wei W, Guang-dong S, Jing S, Shu-jun L, Ji W, Xiao-hong X, Li-ning M (2013) Spontaneous type 2 diabetic rodent models. J Diabetes Res. 2013:401723
Google Scholar
Gaurav G, Ridhima W, Parijat P, Sachin Kumar S, Monica G, Saurabh S (2020) Obesity and diabetes: pathophysiology of obesity-induced hyperglycemia and insulin resistance. Pathophysiology of Obesity-Induced Health Complications. pp 81-97
Nasimeh V, Farzaneh R, Ahmad RS, Sharifeh K, Gholamreza D, Gilda E (2018) Novel high-fat diet formulation and streptozotocin treatment for induction of prediabetes and type 2 diabetes in rats. Adv Biomed Res. 7:107
Article
CAS
Google Scholar
Chinedum OE, Kate CE, Sonia C, Udeme NE (2013) Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans. J Diabetes Metab Disord. 12:60
Article
CAS
Google Scholar
Abdulrahman MS, Hannah MB, Arun VED, Tiffany CYT, Lindsay MP, Jeremy GT (2018) The effect of streptozotocin-induced hyperglycemia on N-and O-linked protein glycosylation in mouse ovary. Glycobiology. 28(11):832–840
Article
CAS
Google Scholar
Philipp AG, Guy AR (2017) The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus. Antioxid Redox Signal. 26(10):501–518
Article
CAS
Google Scholar
Gvazava IG, Rogovaya OS, Borisov MA, Vorotelyak EA, Vasiliev AV (2018) Pathogenesis of type 1 diabetes mellitus and rodent experimental models. Acta Naturae. 10(1):24–33
Article
CAS
Google Scholar
Wu M-Y, Giou-TY T-TL, Chia JL (2018) The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy. Oxid Med Cell Longev. 2018:1–13
CAS
Google Scholar
Arwa MT, Nahdi A, Annie J, Haider R (2017) Elucidation of molecular mechanisms of streptozotocin-induced oxidative stress, apoptosis, and mitochondrial dysfunction in Rin-5F pancreatic β-cells. Oxid Med Cell Longev. 2017:7054272
Google Scholar
Kahraman S, Aydin C, Elpek GO, Dirice E, Sanlioglu AD (2015) Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions. J Diabetes Res. 2015:450128
Article
CAS
Google Scholar
Nidal AQ, Adnan AB (2015) Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats. Drug Des DevelTher. 9:2515–2525
Google Scholar
Jiali L, Lina H, Leilei Z, Yerong Y (2016) Free fatty acids, not triglycerides, are associated with non-alcoholic liver injury progression in high fat diet induced obese rats. Lipids Health Dis. 15:27
Article
CAS
Google Scholar
Snel M, Jonker JT, Schoones J, Lamb H, de Roos A, Pijl H (2012) Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions. Int J Endocrinol. 2012:983814
Article
CAS
Google Scholar
Sotirios T, Alexios SA, Evangelos O, George-Aggelos P, Georgia V, Spyridon P (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol. 14(1):50–59
Article
Google Scholar
Konstantinos P, Maciej B, Eleni B, Manfredi R, Michael E (2018) Complications of diabetes 2017. Diabetes Res. 2018:3086167
Google Scholar
Valeska O, Soumyalekshmi N, Omar E, Claudio A, Carlos S, Felipe A (2018) Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 17:122
Article
CAS
Google Scholar
Tobon VJC, Cuevas E, Torres RMA (2014) CNS Neurol. Disord Drug Targets 13(9):1615–1626
Article
CAS
Google Scholar
Xing L, Gao HL, Dai GY, Sun HM, Xu HQ (2016) Food advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway. Chin J Nat Med. 14(11):844–855
Google Scholar
Mitra T, Dilek GY, Abd AT, Dinesh S, Frank LB, Hassan F (2017) Diabetic neuropathy: current status and future prospects. journal of diabetes research. 2017:1-2
Aslam A, Singh J, Rajbhandari S (2014) Pathogenesis of painful diabetic neuropathy. Pain Res Treat. 2014:412041
Google Scholar
Chun-Pai Y, Cheng-Chieh L, Chia-Ing L, Chiu-Shongn L (2015) Cardiovascular risk factors increase the risks of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. Medicine (Baltimore). 94(42):e1783
Article
CAS
Google Scholar
Sachin V, Suryavanshi, YA, Kulkarni (2017) NF-κβ: a potential target in the management of vascular complications of diabetes. Front Pharmacol. 8:798.
Su Bin C, Won SE, Min JS, Hyun JK, Jung HP, Yeon JC (2019) Transduced tat-aldose reductase protects hippocampal neuronal cells against oxidative stress-induced damage. Exp Neurobiol. 28(5):612–627
Article
Google Scholar
Chunkui Z, Limin W, Fengming N, Wei J, Jiang W, Hongliang Z (2014) Critical illness polyneuropathy and myopathy: a systematic review. Neural Regen Res. 9(1):101–110.
Article
Google Scholar
Lara K, Melanie JM, Anna JV, Anna LO (2019) Obesity-induced TNFα and IL-6 signaling: the missing link between obesity and inflammation—driven liver and colorectal cancers. Cancers (Basel). 11(1):24
Google Scholar
Shreena JD, Ben P, Avraham R (2018) Mechanisms of phytonutrient modulation of Cyclooxygenase-2 (COX-2) and inflammation related to cancer. Nutr Cancer. 70(3):350–375
Article
CAS
Google Scholar
Wei C, Tuo Y, Huan L, Lijuan H, Kai Z, Xiaoming H (2019) Peroxisome proliferator-activated receptor γ (PPARγ): a master gatekeeper in CNS injury and repair. Prog Neurobiol. 163(164):27–58
Google Scholar
Frederik P (2011) Peter R (2018) Diagnosis of diabetic kidney disease: state of the art and future perspective. Kidney Int Suppl 8(1):2–7
Google Scholar
Pérez-Morales RE, del Pino MD, Valdivielso JM, Ortiz A, Mora-Fernández C, Navarro-González JF (2019) Inflammation in diabetic kidney disease. Nephron. 143:12–16
Article
CAS
Google Scholar
Javier DC, Desirée Luis R, Ernesto MN, Víctor GT, Carolina HC, Carla F (2020) Inflammatory targets in diabetic nephropathy. J Clin Med. 9(2):458
Article
CAS
Google Scholar
Haisong Z, Shao CS (2015) NF-κB in inflammation and renal diseases. Cell Biosci. 5:63
Article
CAS
Google Scholar
Mariana RS, van der EM H, Lie Mulder H, Jolanda MS, Izabela A, Rodenhuis Z (2016) Mechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cells. Sci Rep. 6:32288
Article
CAS
Google Scholar
Patrick L, Pascal C, Veronique R, Edward GL, Mingyi W (2015) Chapter 2 - cellular and molecular determinants of arterial aging. Early Vascular Aging (EVA). 2015:7–16
Google Scholar
Ning S, Friedrich T, Linlin G (2019) NFκB and kidney injury. Front Immunol. 10:815
Article
CAS
Google Scholar
Nyasha C, Ophius M, Hilda M (2013) Microalbuminuria in patients with chronic kidney disease at Parirenyatwa Hospital in Zimbabwe. Pan Afr Med J. 14:39
Google Scholar
Meng XM, Tang PM, Li J, Lan HY (2015) TGF-β/Smad signaling in renal fibrosis. Front Physiol. 6:82
Article
Google Scholar
Temitope IA, LeiDu MH, Xueyan Z, QianX U, Chowdhury A, Ying S (2020) Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy. Biomed Pharmacother. 123:109732
Article
CAS
Google Scholar
Martin MN, Michael WU (2015) Diabetic retinopathy - ocular complications of diabetes mellitus. World J Diabetes. 6(3):489–499
Article
Google Scholar
Zhang K, Ferreyra HA, Grob S, Bedell M, Zhang JJ (2012) Diabetic retinopathy: genetics and etiologic mechanisms. In: D.R. Hinton, 5th edn. Elsevier, London
Google Scholar
Musat O, Cernat C, Labib M, Gheorghe A, Toma O, Zamfir M (2015) Diabetic macular edema. Rom J Ophthalmol. 59(3):133–136
Google Scholar
Ryan L, Tien YW, Charumathi S (2015) Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond) 2:17
Article
Google Scholar
Safi SZ, Qvist R, Kumar S, Batumalaie K, Ismail IS (2014) Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targets. Biomed Res Int. 2014:801269
Article
CAS
Google Scholar
Małgorzata N, Andrzej G (2016) The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. 2016:3164734
Google Scholar
Shinwan K, Jan TV, Borna R (2019) Cytokines in inflammatory disease. Int J Mol Sci. 20(23):6008
Article
CAS
Google Scholar
Noboru T, Shinichi T, Sadanobu N (2011) Nitric oxide-mediated coronary flow regulation in patients with coronary artery disease: recent advances. Int J Angiol. 20(3):121–134
Article
Google Scholar
Sayon R, Shruti A, Sumon R (2016) Retinal fibrosis in diabetic retinopathy. Exp Eye Res. 142:71–75
Article
CAS
Google Scholar
Kowluru RA, Zhong Q, Santos JM (2012) Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9. Expert. Opin Invest Drugs. 21(6):797–805
Article
CAS
Google Scholar
Kowluru RA, Shan Y, Mishra M (2016) Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy. Lab Invest. 96(10):1040–1049
Article
CAS
Google Scholar
Vinay K, Abul A, Jon A (2014) Robbins & cotran pathologic basis of disease pathological basis of disease. 10th edition
Gregor MF, Hotamisligi GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol. 29:415–445
Article
CAS
Google Scholar
Yacir B, Mohammed T (2019) Molecular mechanisms underlying obesity-induced hypothalamic inflammation and insulin resistance: pivotal role of resistin/TLR4 pathways. Front Endocrinol (Lausanne) 10:140
Article
Google Scholar
Linlin C, Huidan D, Hengmin C, Jing F, Zhicai Z, Junliang D (2018) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9(6):7204–7218
Article
Google Scholar
Jais A, Brüning JC (2017) Hypothalamic inflammation in obesity and metabolic disease. J Clin Invest. 127(1):24–32
Article
Google Scholar
Estefania BM, Zaida AJ, Aranzazu MM, Francesca I, Irene EL, Sandra LD (2019) Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues. J Clin Med. 8(9):1385
Article
CAS
Google Scholar
Copps KD, White MF (2012) Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia. 55(10):2565–2582
Article
CAS
Google Scholar
Chen Y, Hung-Yun L, Ning-Chun L, Janet DS, Shuyuan Y, Lei-Ya F (2013) Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB–mediated PTP1B expression. Diabetes. 62(2):411–423
Article
CAS
Google Scholar
Santiago V, Julie CK, Tamera B, Dae YJ, Jason KK, Roger JD (2013) Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway. Genes Dev. 27(21):2345–2355
Article
CAS
Google Scholar
Douglass JD, Dorfman MD, Fasnacht R, Shaffer LD, Thaler JP (2017) Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation. Mol Metab 6(4):366–373
Article
CAS
Google Scholar
Zhuo F, Elizabeth RG, Dongmin L (2013) Regulation of insulin synthesis and secretion and pancreatic beta-cell dysfunction in diabetes. Curr Diabetes Rev. 9(1):25–53
Article
Google Scholar
Fernanda G, Felice D, Sergio T (2017) Getting a “GRiP” on hypothalamic endoplasmic reticulum stress to combat obesity. Diabetes. 66(1):17–19
Article
CAS
Google Scholar
Aberdein N, Dambrino RJ, Carmo JM, Wang Z, Mitchell LE, Drummond HA (2018) Role of PTP1B in POMC neurons during chronic high-fat diet: sex differences in regulation of liver lipids and glucose tolerance. Am J Physiol Regul Integr Comp Physiol. 314(3):R478–R488
Article
CAS
Google Scholar
Rogero MM, Calder PC (2018) Obesity, inflammation, Toll-like receptor 4 and fatty acids. Nutrients. 10(4):E432
Article
CAS
Google Scholar
Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18(8):1279–1285
Article
CAS
Google Scholar
Benomar Y, Amine H, Crépin D, Rifai S, Riffault L, Gertler A (2016) Central resistin/TLR4 impairs adiponectin signaling, contributing to insulin and FGF21 resistance. Diabetes. 65(4):913–926
Article
CAS
Google Scholar
Reis WYC, Gao Y, Tschöp MH (2015) Brain innate immunity regulates hypothalamic actuate neuronal activity and feeding behavior. Endocrinology 156(4):1303–1315
Article
CAS
Google Scholar
Wang CH, Wang PJ, Hsieh YC, Lo S, Lee YC, Chen YC (2018) Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties. Oncogene. 37(5):589–600
Article
CAS
Google Scholar
María R, Cristina P, Eduardo M, Nilda G, Carmen M, Fernández M (2018) Central s-resistin deficiency ameliorates hypothalamic inflammation and increases whole body insulin sensitivity. Sci Rep. 8:3921
Article
CAS
Google Scholar
Maggie SB, Derek KH, Jessica NK, Kelsey AS, Mario K (2018) Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus. Compr Physiol. 9(1):1–58
Google Scholar
Md SJ, Sarah MW, Qizhi Y, Changyi C (2012) Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 165(3):622–632
Article
CAS
Google Scholar
Mostafazadeh M, Haiaty S, Rastqar A, Keshvari M (2018) Correlation between resistin level and metabolic syndrome component: a review. HormMetab Res. 50(7):521–536
CAS
Google Scholar
Pine GM, Batugedara HM, Nair MG (2018) Here, there and everywhere: resistin-like molecules in infection, inflammation, and metabolic disorders. Cytokine. 110:442–451
Article
CAS
Google Scholar
Hannan AF, Culligan KG (2015) Human resistin and the RELM of inflammation in diabesity. Diabetol Metab Syndr. 7:54
Article
CAS
Google Scholar
Jérémie B, André KC, Ronald K (2014) Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol. 6(1):a009191
Article
CAS
Google Scholar
Cheng KK, Lam KS, Wang B, Xu A (2014) Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Pract. Res Clin Endocrinol Metab. 28(1):3–13
Article
CAS
Google Scholar
Miao J, Benomar Y, Rifai S, Poizat G, Riffault L, Crépin D, Taouis M (2018) Resistin inhibits neuronal autophagy through Toll-like receptor 4. J Endocrinol. 238(1):77–89
Article
CAS
Google Scholar
André C, Guzman QO, Rey C, Rémus-Borel J, Clark S, Castellanos JA (2017) Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation. Diabetes. 66(4):908–919
Article
CAS
Google Scholar