From: Most promising solid dispersion technique of oral dispersible tablet
Sr. no | Drug candidate | Carrier used | Solid dispersion technique used | Ref. no |
---|---|---|---|---|
1 | Lumacaft | HPMC | Spray drying | [4] |
2 | Ritonavir | PVP | Melt extrusion | [4] |
3 | Traconazole | HPMC | Melt extrusion | [4] |
4 | Iopinavir and ritonavir | PVP or polyvinyl acetate | Melt extrusion | [9] |
5 | Torcetrapib | HPMC acetate succinate | Spray drying | [9] |
6 | Ibuprofen | Various like starch 1500 PVP K 30 | Melt extrusion | |
7 | Verapamil | Various | Melt extrusion | [9] |
8 | Troglitazone | PVP | Melt extrusion | [9] |
9 | Tacrolimus | HPMC | Melt extrusion | [9] |
10 | Etravirine | HPMC | Spray drying | [9] |
11 | Everolimus | HPMC | Melt or spray drying | [9] |
12 | Nifedipine | PVP or polaxomer | Melt or absorb on carrier | [9] |
13 | Griseofulvin | PEG | Melt process | [9] |
14 | Itraconazole | HPMC, Gelucire 50/13, compritol 888ATOO | Spray drying | |
15 | Nabilone | Providone | – | [9] |
16 | Telaprevir | HPMC | Spray drying | [38] |
17 | Nilvadipine | HPMC | Solvent evaporation method | [38] |
18 | Vemurafinib | HPMC | Co-precipitation | [38] |
19 | Ivacaftor | HPMC | Spray drying | [38] |
20 | Tacrolimus | HPMC | Spray drying | [38] |
21 | Everolimus | HPMC | Spray drying | [38] |
22 | Silymarin | PVP K 17 | Supercritical fluid technology | [39] |
23 | Polypeptide-K | Trehalose Tween 80 | Spray drying | [40] |
24 | Valsartan | PEG 6000 HPMC-100 kV | Freeze drying | [41] |
25 | Curcumin | Eudragit EPO | Solvent evaporation method | [42] |
26 | Tadalafin | PVP, malic acid or meglumine and aerosil 200 | Solvent evaporation method | [43] |
27 | Pseudomonas podoviridine phase PEV2 | Trehalose, mannitol, l-leucine | Spray drying | [44] |
28 | Paracetamol | Ethyl cellulose, mesoporous silica | Fluid bed system | [45] |
29 | Itraconazole | Sucrose | Centrifugal spinning method | [46] |
30 | Olanzapine | Sucrose, pregelatinized starch, sodium starch, glycolate | Centrifugal spinning method | |
31 | Piroxicam | Sucrose | Centrifugal spinning method | [46] |
32 | Atrovastatin | Mannitol, PEG 4000, PVP K 30 | Hot melt and solvent evaporation method | [48] |
33 | Alprazolam | PEG 6000, PVP K 30 | Solvent evaporation | [49] |
34 | Aceciofenac | Starch phosphate, Gelucire 50/13 | Kneading method | [50] |
35 | Carvedilol | PEG 6000, Polaxomer407, HPMC, SSG | Fusion and solvent evaporation | [51] |
36 | Cefdinir | PVP K 30, PEG 4000 | Melt fusion and solvent evaporation | [52] |
37 | Diacerein | PVP K 30, HPMC | Solvent evaporation | [53] |
38 | Etoricoxib | Lactose, sucrose, mannitol | Solvent evaporation | [54] |
39 | Glipizide | HPMC, croscarmellose | Solvent evaporation | [55] |
40 | Mefenamic acid | PEG 6000, PVP K 30, HPMC, MCC | Kneading method | [56] |
41 | Nalidixic acid | PVP, beta cyclodextrin, SSG | Solvent evaporation method | [57] |
42 | Rofecoxib | PEG 6000, PVP K 30 | Fusion and solvent evaporation method | [58] |
43 | Simvastatin | PEG 4000, PVP K 30 | Solvent evaporation method | [59] |
44 | Stranidazole | PEG 4000, PVP K 30 | Solvent evaporation method | [60] |
45 | Meloxicam | PVP PEG 6000 | Solvent evaporation method | [61] |
46 | Telmisartan | Gelucire 43/01, polaxomer407, PVP-K 30, HPMC E4, PEG 6000 | Fusion method | [62] |
47 | Gliclazide | PEG 4000, PEG 6000, PVP K 30 | Fusion and solvent evaporation method | [63] |
48 | Proglitazone | PEG 4000, PEG 6000, PEG 20000 | Hot melt method Microwave and kneading method | [64] |
49 | Carbamazepine | Croscarmellose, SSG | Solvent evaporation method | [65] |
50 | Mesalamine | SLS, urea, methanol | Kneading method | [66] |
51 | Ketoprofen | PVP K 30, urea, mannitol, Tween 80 | Solvent evaporation method | [67] |
52 | Indomethacin | Lactose monohydrate, PEG 6000, HPMC, povdone | Kneading method | [68] |
53 | Clonazepam | PEG 6000, HPMC, polaxomer 407 | Solvent evaporation method | [69] |
54 | Telmisartan | Beta cyclodextrin, MCC PH 102, polaxomer 188,400 | Solvent evaporation method | |
55 | Carvediol | Beta cyclodextrin, MCC PH 102, polaxomer 188 | Solvent evaporation method | [72] |
55 | Chlorpheniramine maleate | PEG 6000 and SSG | Fusion method | [73] |
56 | Nevirapine | Urea and PEG | Kneading method | [74] |