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Table 2 Recent study of oral dispersible tablets

From: Most promising solid dispersion technique of oral dispersible tablet

Sr. no

Drug candidate

Carrier used

Solid dispersion technique used

Ref. no

1

Lumacaft

HPMC

Spray drying

[4]

2

Ritonavir

PVP

Melt extrusion

[4]

3

Traconazole

HPMC

Melt extrusion

[4]

4

Iopinavir and ritonavir

PVP or polyvinyl acetate

Melt extrusion

[9]

5

Torcetrapib

HPMC acetate succinate

Spray drying

[9]

6

Ibuprofen

Various like starch 1500 PVP K 30

Melt extrusion

[9, 36]

7

Verapamil

Various

Melt extrusion

[9]

8

Troglitazone

PVP

Melt extrusion

[9]

9

Tacrolimus

HPMC

Melt extrusion

[9]

10

Etravirine

HPMC

Spray drying

[9]

11

Everolimus

HPMC

Melt or spray drying

[9]

12

Nifedipine

PVP or polaxomer

Melt or absorb on carrier

[9]

13

Griseofulvin

PEG

Melt process

[9]

14

Itraconazole

HPMC, Gelucire 50/13, compritol 888ATOO

Spray drying

[9, 37]

15

Nabilone

Providone

–

[9]

16

Telaprevir

HPMC

Spray drying

[38]

17

Nilvadipine

HPMC

Solvent evaporation method

[38]

18

Vemurafinib

HPMC

Co-precipitation

[38]

19

Ivacaftor

HPMC

Spray drying

[38]

20

Tacrolimus

HPMC

Spray drying

[38]

21

Everolimus

HPMC

Spray drying

[38]

22

Silymarin

PVP K 17

Supercritical fluid technology

[39]

23

Polypeptide-K

Trehalose Tween 80

Spray drying

[40]

24

Valsartan

PEG 6000 HPMC-100 kV

Freeze drying

[41]

25

Curcumin

Eudragit EPO

Solvent evaporation method

[42]

26

Tadalafin

PVP, malic acid or meglumine and aerosil 200

Solvent evaporation method

[43]

27

Pseudomonas podoviridine phase PEV2

Trehalose, mannitol, l-leucine

Spray drying

[44]

28

Paracetamol

Ethyl cellulose, mesoporous silica

Fluid bed system

[45]

29

Itraconazole

Sucrose

Centrifugal spinning method

[46]

30

Olanzapine

Sucrose, pregelatinized starch, sodium starch, glycolate

Centrifugal spinning method

[46, 47]

31

Piroxicam

Sucrose

Centrifugal spinning method

[46]

32

Atrovastatin

Mannitol, PEG 4000, PVP K 30

Hot melt and solvent evaporation method

[48]

33

Alprazolam

PEG 6000, PVP K 30

Solvent evaporation

[49]

34

Aceciofenac

Starch phosphate, Gelucire 50/13

Kneading method

[50]

35

Carvedilol

PEG 6000, Polaxomer407, HPMC, SSG

Fusion and solvent evaporation

[51]

36

Cefdinir

PVP K 30, PEG 4000

Melt fusion and solvent evaporation

[52]

37

Diacerein

PVP K 30, HPMC

Solvent evaporation

[53]

38

Etoricoxib

Lactose, sucrose, mannitol

Solvent evaporation

[54]

39

Glipizide

HPMC, croscarmellose

Solvent evaporation

[55]

40

Mefenamic acid

PEG 6000, PVP K 30, HPMC, MCC

Kneading method

[56]

41

Nalidixic acid

PVP, beta cyclodextrin, SSG

Solvent evaporation method

[57]

42

Rofecoxib

PEG 6000, PVP K 30

Fusion and solvent evaporation method

[58]

43

Simvastatin

PEG 4000, PVP K 30

Solvent evaporation method

[59]

44

Stranidazole

PEG 4000, PVP K 30

Solvent evaporation method

[60]

45

Meloxicam

PVP PEG 6000

Solvent evaporation method

[61]

46

Telmisartan

Gelucire 43/01, polaxomer407, PVP-K 30, HPMC E4, PEG 6000

Fusion method

[62]

47

Gliclazide

PEG 4000, PEG 6000, PVP K 30

Fusion and solvent evaporation method

[63]

48

Proglitazone

PEG 4000, PEG 6000, PEG 20000

Hot melt method

Microwave and kneading method

[64]

49

Carbamazepine

Croscarmellose, SSG

Solvent evaporation method

[65]

50

Mesalamine

SLS, urea, methanol

Kneading method

[66]

51

Ketoprofen

PVP K 30, urea, mannitol, Tween 80

Solvent evaporation method

[67]

52

Indomethacin

Lactose monohydrate, PEG 6000, HPMC, povdone

Kneading method

[68]

53

Clonazepam

PEG 6000, HPMC, polaxomer 407

Solvent evaporation method

[69]

54

Telmisartan

Beta cyclodextrin, MCC PH 102, polaxomer 188,400

Solvent evaporation method

[70, 71]

55

Carvediol

Beta cyclodextrin, MCC PH 102, polaxomer 188

Solvent evaporation method

[72]

55

Chlorpheniramine maleate

PEG 6000 and SSG

Fusion method

[73]

56

Nevirapine

Urea and PEG

Kneading method

[74]