Factorial design approach to fabricate and optimize floating tablets based on combination of natural polymer and rice bran wax

Beni-Suef University Journal of Basic and Applied Sciences

Table 7 Pre-compression parameters of batches (F1 to F9) using factorial design

Formulation Code	Loose bulk density (gm/cm³)*	Tapped bulk density (gm/cm³)*	Hausner ratio (HR)*	Carr’s index (CI)*	Angle of repose (θ°)*
F1	0.745 ± 0.01	0.838 ± 0.00	1.1248 ± 0.01	11.0978 ± 0.06	21.17 ± 0.21
F2	0.732 ± 0.01	0.822 ± 0.01	1.1229 ± 0.06	10.9489 ± 0.02	21.19 ± 0.58
F3	0.743 ± 0.00	0.836 ± 0.01	1.1251 ± 0.08	11.1244 ± 0.12	20.54 ± 0.49
F4	0.743 ± 0.02	0.836 ± 0.02	1.1251 ± 0.03	11.124 ± 0.18	22.11 ± 0.21
F5	0.732 ± 0.00	0.822 ± 0.01	1.1229 ± 0.09	10.9489 ± 0.20	20.82 ± 0.11
F6	0.733 ± 0.01	0.823 ± 0.02	1.1227 ± 0.04	10.935 ± 0.16	20.29 ± 0.21
F7	0.745 ± 0.01	0.838 ± 0.00	1.1248 ± 0.03	11.0978 ± 0.15	21.39 ± 0.47
F8	0.732 ± 0.01	0.822 ± 0.01	1.1229 ± 0.06	10.9489 ± 0.09	20.59 ± 0.50
F9	0.728 ± 0.03	0.817 ± 0.01	1.1222 ± 0.02	10.8935 ± 0.08	19.58 ± 0.49
C1^a	0.751 ± 0.02	0.823 ± 0.02	1.0958 ± 0.09	8.74848 ± 0.15	23.24 ± 0.18
C2 ^a	0.746 ± 0.01	0.830 ± 0.01	1.1126 ± 0.10	10.1204 ± 0.21	24.32 ± 0.11
C3 ^a	0.741 ± 0.07	0.825 ± 0.04	1.113 ± 0.60	10.1818 ± 0.26	22.48 ± 0.21