Factorial design approach to fabricate and optimize floating tablets based on combination of natural polymer and rice bran wax

Beni-Suef University Journal of Basic and Applied Sciences

Table 9 Factorial design and their observed response values in gastroretentive tablets

Formulation code	Guar Gum (mg) (X1 = A)	RBW (mg) (X2 = B)	Responses*
Formulation code	Guar Gum (mg) (X1 = A)	RBW (mg) (X2 = B)	FLT (s)	SI	%CDR
F1	20 (− 1)	25 (+ 1)	10 ± 1.154	79.63 ± 0.22	94.21 ± 0.57
F2	30 (+ 1)	20 (0)	10 ± 3.60	80.48 ± 0.55	89.68 ± 0.26
F3	20 (− 1)	20 (0)	15 ± 2.51	82.31 ± 1.21	96.24 ± 0.85
F4	20 (− 1)	15 (− 1)	15 ± 1.73	86.62 ± 0.20	98.28 ± 0.48
F5	30 (+ 1)	15 (− 1)	20 ± 2.88	88.01 ± 0.28	87.59 ± 0.39
F6	25 (0)	15 (− 1)	20 ± 2.88	88.63 ± 0.375	86.89 ± 0.37
F7	25 (0)	25 (+ 1)	22 ± 2.51	90.31 ± 0.739	85.53 ± 0.41
F8	30 (+ 1)	25 (+ 1)	25 ± 10.40	85.02 ± 0.49	88.86 ± 0.43
F9	25 (0)	20 (0)	27 ± 2.47	89.68 ± 1.36	88.98 ± 0.51
C1 ^a	19.75	14.92	28 ± 1.23	82 ± 1.21	94.20 ± 0.32
C2 ^a	24.85	19.64	27 ± 2.30	80.89 ± 1.34	89.30 ± 0.63
C3 ^a	29.80	24.78	28 ± 2.0	88.96 ± 1.82	92.24 ± 0.75

*Values are expressed as mean ± S.D., n = 3*; ^aExtra design check point batches