Route of administration | Disadvantages of conventional formulations | Benefits of nanosuspensions |
---|---|---|
Oral | Slow onset of action/poor absorption | Rapid onset of action/improved solubility so improved bioavailability |
Ocular | Lachrymal wash off/low bioavailability | Higher bioavailability/dose consistency |
Intravenous | Poor dissolution/nonspecific action | Rapid dissolution/tissue targeting |
Intramuscular | Low patient compliance due to pain | Reduced tissue irritation |
Inhalations | Low bioavailability due to low solubility | Rapid dissolution/high bioavailability/dose regulation |