Skip to main content

Correspondence on “piperine as a potential molecule for disease prevention and management

Dear Editor,

We would like to share ideas on the publication “Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials [1]”. Tripathi et al. concluded that “Piperine treatment has also been evidenced to decrease lipid ……. [1].” We agree that piperine might be useful in management of disease. We must carefully assess the conclusions of the current paper by Tripathi et al. because it is a significant report that may be generalized for therapeutic use. The purpose of this correspondence is to provide some additional information that should be examined if piperine is to be utilized in a therapeutic context.

As Ahemed et al. noted, there are few studies on piperine and data on human subjects are limited. A recent report by et al. also showed that piperine is possible useful for management of coronavirus disease 2019 (COVID-19) [2]. A topic that might be a concern that it is not used in human is its toxic property. Piperine can cause liver problem and it can increase toxic effect if administered with other drugs [3, 4]. There is a need for finding for a good pharmaceutic process to prepare a safe piperine before it can be clinically used [3]. This requires a good evaluation on both pharmabiological actions and toxicological profiles of the product derived from the newly proposed pharmacological process.

Availability of data and materials

Not applicable.

Abbreviations

COVID-19L:

Coronavirus disease 2010

References

  1. Tripathi AK, Ray AK, Mishra SK (2022) Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials. Beni Suef Univ J Basic Appl Sci 11(1):16

    Article  Google Scholar 

  2. Yadav SS, Singh MK, Hussain S, Dwivedi P, Khattri S, Singh K (2022) Therapeutic spectrum of piperine for clinical practice: a scoping review. Crit Rev Food Sci Nutr 7:1–28

    Article  Google Scholar 

  3. Saha M, Sikder P, Saha A, Shah S, Sultana S, Emran T, Banik A, Islam Z, Islam MS, Sharker SM, Reza HM (2022) QbD approach towards robust design space for flutamide/piperineself-emulsifying drug delivery system with reduced liver injury. AAPS PharmSciTech 23(1):62

    CAS  Article  Google Scholar 

  4. Saetang J, Tedasen A, Sangkhathat S, Sangkaew N, Dokduang S, Prompat N, Taraporn S, Graidist P (2022) The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats. Pharm Biol 60(1):96–107

    CAS  Article  Google Scholar 

Download references

Acknowledgements

None.

Funding

None.

Author information

Authors and Affiliations

Authors

Contributions

RM: 50% (1a) Substantial contributions to study conception and design; (1b) Substantial contributions to acquisition of data; (1c) Substantial contributions to analysis and interpretation of data. (2) Drafting the article or revising it critically for important intellectual content. (3) Final approval of the version of the article to be published. VW: 50% (1a) Substantial contributions to study conception and design; (1b) Substantial contributions to acquisition of data; (1c) Substantial contributions to analysis and interpretation of data. (2) Drafting the article or revising it critically for important intellectual content. (3) Final approval of the version of the article to be published. Both authors read and approved the final manuscript.

Corresponding author

Correspondence to Rujittika Mungmunpuntipantip.

Ethics declarations

Ethical approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

Authors are from poor developing country and cannot pay for any charge and ask for full waiving for this correspondence letter.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mungmunpuntipantip, R., Wiwanitkit, V. Correspondence on “piperine as a potential molecule for disease prevention and management. Beni-Suef Univ J Basic Appl Sci 11, 44 (2022). https://doi.org/10.1186/s43088-022-00226-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s43088-022-00226-y