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Table 5 Examples of the bacteriocin in the clinical applications

From: Bacteriocins from lactic acid bacteria: purification strategies and applications in food and medical industries: a review

Bacteriocins Producing microorganism Target organism(s) Clinical application References
Pediocin PA-1 P. acidilactici UL5 L. monocytogenes Prevent intestinal infection in mouse model Dabour et al. [38]
Bacteriocin CC2 Enterococcus faecium DSM 20,477 Streptococcus mutans Prevent oral cavity Ng et al. [98, 99]
Bacteriocin AS-48 Enterococcus faecalis UGRA10 Trypanosoma cruzi Chagas treatment Martín-Escolano et al. [89]
Bacteriocin AS-48 Enterococcus faecalis UGRA10 Propionibacterium acnes Treatment of dermatological diseases Cebrián et al. [26]
Pediocin PA-1/AcH, Nisin Z L. lactic MM19, P. acidilactici MM33 VRE Reduce intestinal colonization by VRE in mouse model Millette et al. [94]
Plantaricin EF L. plantarum Mucispirillum and Parabacteroides Treatment of acute inflammatory bowel disease Yin et al. [155]
enterocin DD14 Enterococcus faecalis 14 Methicillin-resistant Staphylococcus aureus (MRSA) Treatment of multidrug-resistant bacteria Belguesmia et al. [16]
Nisin L. lactis ESI 515 S. aureus, S. epidermis Treatment of staphylococcal mastitis during lactation in human Fernández et al. [47]
Nisin Lactococcus lactis subsp. lactis SW1088 tumor cell line Anti-cancer therapy Zainodini et al. [158]
Bacteriocin-like inhibitory substance Enterococcus faecium DSM 20,477 Streptococcus mutans, Candida albicans Prevention of dental caries Ng et al. [98, 99]