Bacteriocins from lactic acid bacteria: purification strategies and applications in food and medical industries: a review

Beni-Suef University Journal of Basic and Applied Sciences

Table 5 Examples of the bacteriocin in the clinical applications

Bacteriocins	Producing microorganism	Target organism(s)	Clinical application	References
Pediocin PA-1	P. acidilactici UL5	L. monocytogenes	Prevent intestinal infection in mouse model	Dabour et al. [38]
Bacteriocin CC2	Enterococcus faecium DSM 20,477	Streptococcus mutans	Prevent oral cavity	Ng et al. [98, 99]
Bacteriocin AS-48	Enterococcus faecalis UGRA10	Trypanosoma cruzi	Chagas treatment	Martín-Escolano et al. [89]
Bacteriocin AS-48	Enterococcus faecalis UGRA10	Propionibacterium acnes	Treatment of dermatological diseases	Cebrián et al. [26]
Pediocin PA-1/AcH, Nisin Z	L. lactic MM19, P. acidilactici MM33	VRE	Reduce intestinal colonization by VRE in mouse model	Millette et al. [94]
Plantaricin EF	L. plantarum	Mucispirillum and Parabacteroides	Treatment of acute inflammatory bowel disease	Yin et al. [155]
enterocin DD14	Enterococcus faecalis 14	Methicillin-resistant Staphylococcus aureus (MRSA)	Treatment of multidrug-resistant bacteria	Belguesmia et al. [16]
Nisin	L. lactis ESI 515	S. aureus, S. epidermis	Treatment of staphylococcal mastitis during lactation in human	Fernández et al. [47]
Nisin	Lactococcus lactis subsp. lactis	SW1088 tumor cell line	Anti-cancer therapy	Zainodini et al. [158]
Bacteriocin-like inhibitory substance	Enterococcus faecium DSM 20,477	Streptococcus mutans, Candida albicans	Prevention of dental caries	Ng et al. [98, 99]