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Table 5 Effect of aqueous extract of B. sapida leaves on selected liver function indices of P. berghei-infected female albino mice

From: Antiplasmodial evaluation of aqueous extract of Blighia sapida K.D. Koenig leaves in Plasmodium berghei (NK65)-infected mice

Groups

Liver: body weight (%)

Serum albumin (g/dL)

Serum globulin (g/dL)

Serum total bilirubin (mg/dL)

Serum direct bilirubin (mg/dL)

Not infected + distilled water

4.63 ± 0.19a

4.30 ± 0.03a

1.73 ± 0.20a

22.57 ± 3.99a

4.22 ± 1.62a

Infected + distilled water

8.70 ± 0.32b

0.97 ± 0.02b

4.96 ± 0.24c

23.65 ± 0.56a

5.04 ± 1.75a

Infected + 5 mg/Kg/day CQ

5.44 ± 0.04a

3.47 ± 0.12a,c

2.80 ± 0.58b

24.08 ± 5.74a

6.72 ± 0.62a,b

Infected + 125 mg/Kg/day of extract

7.20 ± 1.00b,c

2.15 ± 0.60d

2.57 ± 0.51a

9.29 ± 3.63b

4.37 ± 1.25a

Infected + 250 mg/Kg/day of extract

6.63 ± 0.35c

3.88 ± 0.68a,c

2.53 ± 0.82a

17.68 ± 1.96a,b

9.79 ± 0.79b

Infected + 500 mg/Kg/day of extract

6.67 ± 0.26c

4.85 ± 0.16c

2.50 ± 0.17a

10.36 ± 1.70b

7.39 ± 0.10a,b

  1. Values are mean ± S.E.M (n = 8)
  2. CQ chloroquine
  3. Values with different alphabet superscripts in the same column are significantly different (P < 0.05)