Erdő F, Bors LA, Farkas D, Bajza Á, Gizurarson S (2018) Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Res Bull 143:155–70
Article
PubMed
Google Scholar
Kakad S, Kshirsagar S (2021) Nose to brain delivery of Efavirenz nano suspension for effective neuro AIDS therapy: in-vitro, in-vivo and pharmacokinetic assessment. Heliyon. https://doi.org/10.53879/id.58.04.11888
Kaul M, Garden GA, Lipton SA (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410:988–994
Article
CAS
PubMed
Google Scholar
Illum L (2003) Nasal drug delivery—possibilities, problems and solutions. J Control Rel 87:187–98
Article
CAS
Google Scholar
Varatharajan L, Thomas SA (2009) The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res 82:A99
Article
CAS
PubMed
PubMed Central
Google Scholar
Nowacek A, Gendelman HE (2009) Nano-ART, neuro-AIDS and CNS drug delivery. Nanomedicine 4:557–574
Article
CAS
PubMed
Google Scholar
Jayant RD, Atluri VSR, Agudelo M, Sagar V, Kaushik A, Nair M (2015) Sustained-release nanoART formulation for the treatment of neuroAIDS. Int J Nanomed 4(10):1077–1093
Article
Google Scholar
Global HIV & AIDS statistics—2020 fact sheet. Accessed online https://www.unaids.org/en/resources/fact-sheet Accesed on 25 Apr 2021
Saravanan M, Asmalash T, Gebrekidan A, Gebreegziabiher D, Araya T, Hilekiros H et al (2018) Nano-medicine as a newly emerging approach to combat Human Immunodeficiency Virus (HIV). Pharm Nanotechnol 9:06
Google Scholar
McArthur JC (2004) HIV dementia: an evolving disease. J Neuroimmunol 157:3–10
Article
CAS
PubMed
Google Scholar
Shapshak P, Kangueane P, Fujimura RK, Commins D, Chiappelli F, Singer E et al (2011) Editorial NeuroAIDS review. AIDS 25:123–141
Article
PubMed
Google Scholar
Djupesland PG (2013) Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review, drug delivery and translational research, vol. 3, Springer, pp 42–62
Delshadi R, Bahrami A, McClements DJ, Moore MD, Williams L (2021) Development of nanoparticle-delivery systems for antiviral agents: a review. J Control Release 331:30–44
Article
CAS
PubMed
PubMed Central
Google Scholar
Kearney BP, Flaherty JF, Shah J (2004) Tenofovir Disoproxil Fumarate clinical pharmacology and pharmacokinetics, vol 43, ClinPharmacokinet
Gallant JE, Deresinski S. Tenofovir Disoproxil Fumarate (2003) Reviews of anti-infective agents. In: Clinical infectious diseases, vol 37. https://academic.oup.com/cid/article/37/7/944/422616
Liner KJ, Ro MJ, Robertson KR (2010) HIV, antiretroviral therapies, and the brain. Curr HIV/AIDS Rep 7:85–91
Article
PubMed
Google Scholar
Vyas TK, Shah L, Amiji MM (2006) Nanoparticulate drug carriers for delivery of HIV/AIDS therapy to viral reservoir sites. Expert Opin Drug Deliv 3:613–628
Article
CAS
PubMed
Google Scholar
Chhabra G, Chuttani K, Mishra AK, Pathak K (2011) Design and development of nanoemulsion drug delivery system of amlodipine besilate for improvement of oral bioavailability. Drug Dev Ind Pharm 37(8):907–916
Article
CAS
PubMed
Google Scholar
Wong HL, Chattopadhyay N, Wu XY, Bendayan R (2010) Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Adv Drug Deliv Rev 62:503–517
Article
CAS
PubMed
Google Scholar
Shafiq-un-Nabi S, Shakeel F, Talegaonkar S, Ali J, Baboota S, Ahuja A, Khar RK, Ali M (2007) Formulation development and optimization using nanoemulsion technique: a technical note. AAPS PharmSciTech 8(2):E12-28. https://doi.org/10.1208/pt0802028
Article
PubMed Central
Google Scholar
Prabhakar K, Afzal SM, Surender G, Kishan V (2013) Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain. ActaPharmaceuticaSinica B 3(5):345–53. https://doi.org/10.1016/j.apsb.2013.08.001
Article
Google Scholar
Pokharkar VB, Jolly MR, Kumbhar DD (2015) Engineering of a hybrid polymer-lipid nanocarrier for the nasal delivery of tenofovirdisoproxil fumarate: physicochemical, molecular, microstructural, and stability evaluation. Eur J Pharm Sci 25(71):99–111
Article
Google Scholar
Laxmi M, Bhardwaj A, Mehta S, Mehta A (2015) Development and characterization of nanoemulsion as carrier for the enhancement of bioavailability of artemether. Artif Cells Nanomed Biotechnol 43(5):334–344. https://doi.org/10.3109/21691401.2014.887018
Article
CAS
PubMed
Google Scholar
Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S (2007) Nanoemulsions as vehicles for transdermal delivery of aceclofenac. AAPS PharmSciTech 8(4):191. https://doi.org/10.1208/pt0804104
Article
PubMed Central
Google Scholar
Cojocaru FD, Botezat D, Gardikiotis I, Uritu CM, Dodi G, Trandafir L, Rezus C, Rezus E, Tamba BI, Mihai CT (2020) Nanomaterials designed for antiviral drug delivery transport across biological barriers. Pharmaceutics 12(2):171. https://doi.org/10.3390/pharmaceutics12020171
Article
CAS
PubMed
PubMed Central
Google Scholar
Mahajan HS, Mahajan MS, Nerkar PP, Agrawal A (2014) Nanoemulsion-based intranasal drug delivery system of saquinavirmesylate for brain targeting. Drug Deliv 21(2):148–154
Article
CAS
PubMed
Google Scholar
Chin LY, Tan JY, Choudhury H, Pandey M, Sisinthy SP, Gorain B (2021) Development and optimization of chitosan coated nanoemulgel of telmisartan for intranasal delivery: a comparative study. J Drug Deliv Sci Technol 62:102341
Article
CAS
Google Scholar
Kumar M, Misra A, Babbar AK, Mishra AK, Mishra P, Pathak K (2008) Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm 358(1–2):285–291. https://doi.org/10.1016/j.ijpharm.2008.03.029
Article
CAS
PubMed
Google Scholar
Ogunwuyi O, Kumari N, Smith KA, Bolshakov O, Adesina S, Gugssa A, Anderson WA, Nekhai S, Akala EO (2016) Antiretroviral drugs-loaded nanoparticles fabricated by dispersion polymerization with potential for HIV/AIDS treatment. Infect Dis 9:21–32. https://doi.org/10.4137/IDRT.S38108
Article
Google Scholar
Belgamwar A, Khan S, Yeole P (2018) Intranasal chitosan-g-HPβCD nanoparticles of efavirenz for the CNS targeting. Artif Cells Nanomed Biotechnol 46(2):374–386
Article
CAS
PubMed
Google Scholar
Kakad SP, Kshirsagar SJ (2021) Development of reverse phase high-performance liquid chromatographic method for the estimation of HIV non-nucleoside reverse transcriptase inhibitor drug efavirenz in the rat brain. Futur J Pharm Sci 7:11. https://doi.org/10.1186/s43094-020-00158-3
Article
Google Scholar
dasNeves J et al (2010) Nanotechnology-based systems for the treatment and prevention of HIV/AIDS. Adv Drug Deliv Rev 62(4–5):458–477. https://doi.org/10.1016/j.addr.2009.11.017
Article
CAS
Google Scholar
Kotta S, Khan AW, Ansari SH, Sharma RK, Ali J (2014) Anti HIV nanoemulsion formulation: optimization and in vitro-in vivo evaluation. Int J Pharm 462(1–2):129–134. https://doi.org/10.1016/j.ijpharm.2013.12.038
Article
CAS
PubMed
Google Scholar
Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, Chourasia MK (2017) Nanoemulsion: concepts, development and applications in drug delivery. J Control Release Off J Control Rel Soc 252:28–49. https://doi.org/10.1016/j.jconrel.2017.03.008
Article
CAS
Google Scholar
Mulam TR, Kshirsagar SJ, Kakad SP (2021) Formulation and optimization of ritonavir nasal nanosuspension for brain targeting. https://doi.org/10.53879/id.58.04.11888
Alukda D, Sturgis T, Youan BC (2011) Formulation of tenofovir-loaded functionalized solid lipid nanoparticles intended for HIV prevention. J Pharm Sci 100(8):3345–3356. https://doi.org/10.1002/jps.22529
Article
CAS
PubMed
PubMed Central
Google Scholar
Ibrahim MA, Shazly GA, Aleanizy FS, Alqahtani FY, Elosaily GM (2019) Formulation and evaluation of docetaxel nanosuspensions: in-vitro evaluation and cytotoxicity. Saudi Pharm J 27(1):49–55
Article
PubMed
Google Scholar
Kuo YC, Chen HH (2009) Entrapment and release of saquinavir using novel cationic solid lipid nanoparticles. Int J Pharm 365(1–2):206–13
CAS
PubMed
Google Scholar
Shah BM, Misra M, Shishoo CJ, Padh H (2015) Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization. Drug Deliv 22(7):918–30
Article
CAS
PubMed
Google Scholar
Sharma D, Maheshwari D, Philip G, Rana R, Bhatia S, Singh M, Gabrani R, Sharma SK, Ali J, Sharma RK, Dang S (2014) Formulation and optimization of polymeric nanoparticles for intranasal delivery of lorazepam using Box-Behnken design: in vitro and in vivo evaluation. Biomed Res Int 2014:156010. https://doi.org/10.1155/2014/156010
Article
CAS
PubMed
PubMed Central
Google Scholar
Kakad SP, Kshirsagar SJ (2020) Neuro-AIDS: current status and challenges to antiretroviral drug therapy (ART) for its treatment. Curr Drug Ther 15(5):469–81. https://doi.org/10.2174/1574885515666200604123046
Article
CAS
Google Scholar
Khalil NM, Carraro E, Cótica LF, Mainardes RM (2011) Potential of polymeric nanoparticles in AIDS treatment and prevention. Expert Opin Drug Deliv 8:95–112
Article
CAS
PubMed
Google Scholar