- Review
- Open access
- Published:
Ethnopharmacology and therapeutic potentials of Oxalis corniculata: an in-depth study
Beni-Suef University Journal of Basic and Applied Sciences volume 13, Article number: 81 (2024)
Abstract
Background
For centuries, plants have been used in the folk medicine of various cultures for their healing properties. It is amazing how nature has provided us with such powerful remedies. Oxalis corniculata (O. corniculata) has always been used traditionally for its medicinal attributes. In Asia, this herbaceous plant is used for treating many gastrointestinal disorders, such as diarrhea and dysentery. In African folk medicine, on the other hand, this herb is used for respiratory diseases, skin diseases, and fever.
Main body
Scientific research has revealed numerous pharmacological potentials of this plant, including antitumor, antimicrobial, antioxidant, anti-inflammatory, and hepatoprotective properties. In addition, studies have indicated that the extract of this plant protects against oxidative stress, inflammation, and various diseases, including cancer and diabetes. Phytochemical analysis of O. corniculata revealed various relevant compounds, including phenolic acids, flavonoids, and alkaloids, which are responsible for its therapeutic properties.
Conclusion
The various constituents of this plant have significant ethnomedicinal potential. The plant is a possible source of extracts and chemical compounds with pharmacological activity. In the future, O. corniculata could have an effective role in the development of modern drugs. The objective of this review is to summarize the current knowledge on the medicinal potential of O. corniculata, including its bioactive compounds, mechanisms of action, and therapeutic applications.
Graphical abstract
![](http://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs43088-024-00541-6/MediaObjects/43088_2024_541_Figa_HTML.png)
1 Background
Oxalis corniculata (O. corniculata) is an herbaceous perennial plant that belongs to the Oxalidaceae family [1] and is known for its clover-like leaves and yellow flowers [2]. Taxonomic studies have placed O. corniculata in the section Corniculatae of the genus Oxalis. This section includes several other species, and taxonomic revisions have been conducted to better understand the morphological delimitation and relationships within this section [3]. It is a cosmopolitan species which is extensively spread in tropical and temperate areas [4, 5]. In some areas, such as Japan, it is considered a non-native species, as it is thought to have been colonized there in prehistoric times [6]. Its exact origin is still uncertain [7]. The plant is often found in habitats such as roadsides and cultivated fields. Concerning its ecological interactions, the butterfly lays its eggs on the leaves of O. corniculata, as these serve as a host for its larvae [8]. The use of this plant has been described in several researches owing to its medicinal possessions and biological activities [9]. It is known to have antioxidant activities and antiradical potential due to its secondary metabolites [10]. The flavonoids found in O. corniculata have been researched for their potential health benefits. These compounds have antioxidant properties, can scavenge free radicals, and may aid in the prevention of coronary heart disease [11]. In addition, studies have investigated the antibacterial effect of the plant, particularly against Staphylococcus aureus biofilms, due to the presence of different bioactive constituents such as alkaloids, phenols, and flavonoids [12, 13]. These properties make this plant valuable in the arenas of medicine and pharmacy.
2 Main text
2.1 Methods
This review on O. corniculata was compiled using literature from six databases: SciFinder, PubChem, ScienceDirect, Scopus, PubMed, Google Scholar, and Web of Science. The articles included in the review were published in English before August 2023 and focused on the various phytochemicals isolated from distinct parts of O. corniculata, the pharmacological activities of the extracts, and their therapeutic uses. The keywords used to retrieve related studies were in vitro systems, virtual screening and animal studies, O. corniculata, creeping wood sorrel, ethnopharmacology, phytochemical constituents, traditional medicine, pharmacological properties, and phytochemistry.
2.2 Botany
This review on O. corniculata was compiled using literature from six databases: SciFinder, PubChem, ScienceDirect, Scopus, PubMed, Google Scholar, and Web of Science. The articles included in the review were published in English before August 2023. This plant is characterized by a slender stem covered with rounded, tipped hairs [14]. The plant’s flower is the smallest compared to other Oxalis species [15]. The species also exhibits an intraspecific polymorphism in leaf color that changes in response to urban heat stress [16]. This is a C3 plant and does not require sodium for its physiological functions [17]. It is considered a weed because it can colonize various environments, including greenhouses [18]. Its distribution in habitats such as roadsides and cultivated fields is further evidence of its weedy character [4]. In addition, its occurrence in various habitats, including fallow land, home gardens, lawns, and public gardens, emphasizes its adaptability to different environmental conditions [19]. The ecological importance of O. corniculata also extends to its influence on understorey vegetation in high biodiversity hotspots, where it has been identified as a species capable of expanding into new habitats under the joint effects of environment and awning alterations [20]. The plant is known for its allelopathic effect, hindering the development and progress of various floras [21, 22]. The species is also known for its long flowering period from February to November and its rapid seedling growth compared to other herbaceous species [23].
2.2.1 Synonyms [24, 25]
- Sanskrit::
-
Amlapatrika, Amlalonika, Ambashta, PÅ«tigandha, Amlika, Amlotaja, Chukrita, Carngeri, Changeri, Cangeri, Chukrika, Shuklika
- English::
-
Indian Sorrel
- Gujarati::
-
Kanjo, Chirbil, Chirmil
- Hindi::
-
Seh, Seh-Patti, Seh-Patti, Tinpatiya; Amili, Khatri-Buti Amrul, Amrulsak, Anboti, Khatari, Khataria, Anboti; Bhilmori, Chalmori; Chuka Tripati, Chukatripati, Cukatripati, Khataro
- Kannada::
-
Putaanipurule, Huli Soppu, Huli Huliche, Hulichikka, Hulihunice, Pullam-Purachi-Sappu, Pullampurachi, Pullampuruchi, Changeri Gida, Majjige Soppu, Majjige Palya, Moorele Huli, Neergoli, Pulibanthunise, Teltuppi, Uppuppina Gida, Huli-Huniche, Pullampurachisappu
- Malayalam::
-
Puliyaral, Pullampurachi, Puliyarila, Poliyarala, Puliyarala
- Marathi::
-
Umbuti, Ambata Chukaa, Bhinsarpati, Aambotee, Ambuti
- Oriya::
-
Duranja, Karanj, Putikaranj
- Punjabi::
-
Papri, Chirbid
- Tamil::
-
Avilo Pattai, Amanitam, Atiyamilaparani, Cenkontai, Cenkottaiccivappi, Civappi5, Kecariyarakkirai, Paliakiri, Kayankaliyatanayaki, Perunkotikkirai, Piliccakkirai, Puli-K-Kirai, Puli-Yarai, Puliakire, Puliccirukirai, Puliiyarai, Pulikkirai, Pulittacirukirai, Puliyaarai, Atacani, Puliyarai, Puliyarani, Amalakam, Ambal, Kaniyatanayaki, Kentika, Puliyancirukirai, Puliyankirai
- Telugu::
-
Anboti Kura, Anbotikura, Ambotikura, Amboti-Kura, Pulichinta, Pulichintaaku, Pulichintaku, Puli-Chintaku, Pulicintaku, Pullachanchali, Tapazi, Nemalinara
- Urdu::
-
Papri, Khatt-I-Buti
2.2.2 Scientific classification [26]
- Kingdom::
-
Plantae
- Division::
-
Magnoliophyta
- Class::
-
Magnoliopsida
- Order::
-
Oxalidales
- Family::
-
Oxalidaceae
- Genus::
-
Oxalis
- Species::
2.3 Traditional uses
O. corniculata is used in folk medicine to alleviate various ailments [27]. In India, this plant is considered astringent, antiscorbutic, cooling, and helpful in the treatment of rectal prolapse, dysentery, fever, and biliousness [28]. In rural parts of Pakistan, Jammu & Kashmir, O. corniculata is one of the most commonly mentioned species used for the treatment of diabetes [29]. The herb is also recognized in folk medicine schemes viz. Siddha, Unani, and Ayurveda [30]. The plant is widely distributed and has been recorded as a common weed in various regions, including Southeast Asia, Tanzania, Egypt, and India [4, 7, 31, 32]. The plant is native to inhabitants of Southeast Asia and is commonly utilized as a remedy in this region [7]. The plant has acclimatized in Japan and other regions of the world [4]. Its versatility and broad spectrum of biological activity make it a valuable medicinal plant [33]. Traditionally, it is also used for the treatment of complications like diarrhea, ulcers in the stomach, toothache, and tonsillitis [13, 28, 34, 35]. In Tanzania, extracts of the plant are used traditionally for medicines [13]. The plant is also commonly used as medicine in Southeast Asia, indicating a long association with the society in the region [7]. Ethnobotanical studies in the Balasore district of Odisha, India, have shown that this plant is consumed as a leafy vegetable by the local communities and reportedly has ethnomedicinal uses against gastrointestinal ailments, especially gastrointestinal disorders and diarrhea [32]. This herb is also used as livestock feed [36]. The plant has been found to have gastroprotective effects, with significant antisecretory and anti-ulcer properties, supporting its traditional use as a remedy for peptic ulcers [35]. The traditional use and bioactivity of this plant suggest its potential as a source of dietary supplements and pharmaceuticals [10].
2.4 Pharmacological activities of Oxalis corniculata
The leaf and whole plant of O. corniculata have been studied for their pharmacological properties. An overview of these activities is presented in Table 1.
2.4.1 Antimicrobial activity
Recent research has revealed that different organic solvents can extract other phytochemicals from plants [71], each with varying antimicrobial activity [72]. The Ethanol and Methanol fractions of O. corniculata have shown notable effectiveness in combating Staphylococcus aureus [48] and its biofilm formation ability [12], along with some clinical isolates of Vibrio cholerae [49] Staphylococci species, Salmonella typhi [50] and some Multi-Drug Resistant (MDR) strains of Citrobacter koseri, Salmonella typhi, and Klebsiella pneumoniae [51]. n-butanol and n-hexane soluble fractions also had significant antimicrobial activity for bacterial strains Shigella dysenteriae, Bacillus subtilis, Salmonella typhi, and strains of fungus, Fusarium solani, Aspergillus flavus, and Aspergillus flexneri [52]. Apart from organic extracts, water extract was also effective against Candida albicans [13]. The cream made out of oil in a water-based emulsion and a 20% fresh leaf extract was also effective against bacterial strains of Escherichia coli and Staphylococcus aureus [53].
2.4.2 Anticancer activity
Several studies have investigated the anticancer potential of O. corniculata. One study suggested that the ethanolic extract may cause apoptosis in the MCF7, a breast cancer cell line, by inducing oxidative stress and can exhibit significant anticancer and antitumor activity in Swiss albino mice [41, 42]. The hydroalcoholic extract and ethyl acetate fraction have demonstrated the ability to inhibit the growth of the Hep-G2 cancer cell line; further molecular docking study with phytoconstituents of O. corniculata demonstrated that among different compounds, apigenin possesses strong binding energy of − 7.90 kcal/mol compared to the standard drug doxorubicin, which possesses − 7.63 kcal/mol against the epidermal growth factor receptor tyrosine kinase [27]. Another in silico study identified isovitexin as a potential Human Papillomavirus (HPV-18) inhibitor that could help treat cervical cancer [73]. Furthermore, a study in Uganda reported different plants with anticancer activity used locally in Uganda. O. corniculata was among the plant species identified for its potential anticancer properties [74]. The exact mechanisms of the anticancer activity of O. corniculata have yet to be fully understood. However, it has been suggested that bioactive constituents, such as quassinoids and flavonoids, may contribute to its anticancer effects [75, 76]. Overall, the available studies suggest that O. corniculata exhibits potential anticancer activity, possibly through its antioxidant properties and induction of apoptosis. The phytochemical composition and biological activities of O. corniculata make it a promising candidate for further investigation and development of novel anticancer agents [5]. However, additional research is warranted to elucidate the underlying mechanisms and potential therapeutic applications of O. corniculata in cancer treatment.
2.4.3 Antioxidant activity
Free radicals can cause damage to the body, but antioxidants offer protection against this by reducing oxidative stress [10]. The antioxidant activity of O. corniculata has been studied from different parts of this plant., including leaves, whole plants, and extracts obtained using other solvents [56]. O. corniculata has been found to contain various phytochemicals that possess antioxidant activity, such as glycosides, phytosterols, tannins, flavonoids, and polyphenols [77, 78]. These compounds have been shown to scavenge free radicals and reduce oxidative stress [79,80,81,82]. Several studies have supported the antioxidant activity of O. corniculata. In one study, the extract from methanol and their sub-fractions of different solvents demonstrated strong antioxidant capabilities when compared to ascorbic acid used as the reference standard [56, 83]. The plant’s methanolic extract showed significant in vivo antioxidant activity in rat paw edema and cotton pellet-induced granuloma formation [55]. In another study, oxidative stress induced by carbon tetrachloride (CCl4) in rats was significantly attenuated by treatment with methanolic extract, as evidenced by a decrease in the levels of liver enzymes [59]. Apart from methanol, ethyl acetate and ethanol fractions also showed the highest antioxidant activity [56, 57]. The acidic polysaccharide, the primary active ingredient in aqueous extract, significantly reduced oxidative damage in the HEK-293 cell line and Caenorhabditis elegans [58]. Moreover, O. corniculata has been traditionally used for various medicinal purposes. According to a study by Rahman et al. (2019), local inhabitants in Pakistan use O. corniculata to treat Vitamin C deficiency and bad mouth smell [84].
2.4.4 Wound healing activity
The petroleum ether and alcohol extracts of O. corniculata, when administered to rats in different models of experimental wounds, showed potential wound-healing activity, as evidenced by their ability to promote granulation tissue formation, collagen synthesis, and wound closure. However, it is essential to note that these findings are based on animal models, and further research is needed to validate these results in human subjects [70].
2.4.5 Antidiarrheal activity
In a study of diarrhea induced by the administration of castor oil in rats, the water extract displayed greater efficacy than the methanolic extract at all doses [44]. In the evaluation of anti-colonization properties, an infant mouse model was exposed to an intragastric challenge with S. flexneri 2a and S. dysenteriae 1. Methanolic extract showed higher efficacy against S. dysenteriae 1 as compared to S. flexneri 2a. Examination of the methanolic extract of the leaf by High-performance Liquid Chromatography (HPLC) revealed the presence of various flavonoids and phenolic acids, such as rutin, p-hydroxybenzoic acid, ferulic acid, which are responsible for the antidiarrheal activity [45].
2.4.6 Anti-inflammatory activity
An experimentally induced in vivo inflammatory bowel disease model showed significant anti-inflammatory activity when treated with ethanolic extract of O. corniculata leaves in rats [46]. In another animal model, ethanolic extract demonstrated anti-inflammatory and analgesic effects in mice with acute peritonitis induced by acetic acid [38]. Apart from ethanolic extract, β-sitosterol isolated using petroleum ether extraction demonstrated dose-dependent anti-inflammatory activity, reducing paw edema in the rat model of carrageenan-induced hind paw edema [47].
2.4.7 Nootropic activity
The ethanolic extract showed potential neuroprotective effects and improved cognitive and motor performance in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model of Parkinson's disease. The potential improvement in memory performance by ethanolic extract might possibly be ascribed due to the occurrence of flavonoids, coumarins, tocopherols, and phenolic acids [69].
2.4.8 Hepatoprotective activity
The liver of rats treated with aqueous leaf extract significantly reduced CCl4-induced increases in serum levels of bilirubin, AST, ALT, and ALP. It only showed less damage than the livers of rats treated with CCl4 [66]. Another study with ethanolic extract showed a membrane-stabilizing effect, which helped protect the liver cells from damage caused by thioacetamide (TAA) in rats [67]. In an in silico study, active compounds of O. corniculata and 30 potential targets, like TP53, AKT1, ALB, and IL6, were employed in network pharmacology and constructed a "drug-active ingredient-target-disease" network. The study identified several biological processes and signaling pathways potentially involved in the anti-hepatic effects [85].
2.4.9 Analgesic activity
The ethanol-derived extract had a remarkable effect on reducing acetic acid-induced twitching in mice, indicating potential analgesic properties compared to the control group [39]. In addition, ethanol extract showed a significant decrease in body torsions and a noticeable reduction in abdominal capillary permeability in mice with acute peritonitis induced by acetic acid [38]. β-Sitosterol, an isolated phytochemical compound from the petroleum ether extract of O. corniculata, exhibits significant analgesic properties in acetic acid-induced twitching in mice. Analgesic properties of β-sitosterol might be because of its capability to either hinder pain perception at nerve terminals or to regulate pain-inducing mediators [47].
2.4.10 Anthelmintic activity
In vitro studies have shown that O. corniculata has potential anthelmintic activity. All three extracts (petroleum ether, methanol, and ethyl acetate) showed significant anthelmintic activity at 400Â mg/mL, with the most potent methanol extract. The methanolic extract caused paralysis and death of earthworms in 11.33 and 41.33Â min, respectively [40].
2.4.11 Antidiabetic activity
Treatment with ethanolic and aqueous extract showed a rectification in the final body weight and level of blood glucose in streptozotocin (STZ) induced hyperglycemia in rats compared to the untreated control group of diabetics [14, 43].
2.4.12 Abortifacient activity
The petroleum ether extract of the whole plant showed more activity than the ethanol extract regarding anti-implantation and abortifacient effects. A 100Â mg/kg body weight dose of the extract from petroleum ether in all six rats resulted in complete pregnancy inhibition [37].
2.4.13 Anti-ulcer activity
Administration of the methanolic extract in an indomethacin-induced ulcer model in rats at doses of 125, 250, and 500Â mg/kg b. w. decreased ulcer score, ulcer index, and number of ulcers in a dose-dependent manner. The presence of flavonoids in the methanolic extract could be the reason for its anti-ulcer effect [35].
2.4.14 Nephroprotective activity
An aqueous extract effectively suppresses the growth of struvite stones grown in a gel medium using the in vitro single diffusion gel growth assay, leading to the stones’ dissolution [68].
2.4.15 Anxiolytic activity
The ethanolic extract showed an anxiolytic effect, as evidenced by improved locomotor activity in the open field test, improved entries into the open arms of the elevated plus-maze test, and decreased fighting episodes [62]. Another study indicated a reduction in anxiety-like behavior in the ethanolic extract-treated groups. Treatments increased the time spent in the open arm of the elevated plus maze and decreased the number of head dips in the hole board test compared to the control group [63]. The methanolic extract also showed neuroprotective activity in mice models of depression in the tail suspension test and the swimming test; methanolic extract-treated groups showed a substantial decline in immobility time compared to the control group [65]. Since 1970, angiotensin-converting enzymes (ACE) have been targeted for hypertension control [86]. The aqueous extract was found to have dose-dependent ACE inhibitory activity in vitro more effectively than the standard ACE inhibitor, captopril, at all doses tested ranging from 10 to 50Â mg/mL [64].
2.4.16 Anti-pyretic activity
The efficacy of the extracts in reducing fever was tested by inducing pyrexia in rats using Brewer's yeast. The administration of a 200Â mg/kg body weight dose of ethanolic extract resulted in a significant reduction in pyrexia from 1 to 4Â h compared to the initial measurement (0Â h) in the same group of animals [39].
2.4.17 Cardioprotective activity
In a study, the potential protective effect of an aqueous extract was investigated in isoproterenol-induced myocardial infarction in rats. Histopathological analysis of cardiac tissue after pretreatment with the aqueous extract showed normal myocardial fibers with mild inflammatory changes in comparison with isoproterenol-treated rats [60].
2.5 Phytochemistry
We have collected information on several phytoconstituents extracted from O. corniculata and provided comprehensive information on their pharmacological activities, chemical structures, IUPAC names, and corresponding references in Table 2. "ChemDraw JS 19.0" was used to create the chemical structures of the phytochemicals found in O. corniculata. https://chemdrawdirect.perkinelmer.cloud/js. PubChem database was used to retrieve the International Union of Pure and Applied Chemistry (IUPAC) chemical names.
2.6 Toxicology of O. corniculata
An acute oral toxicity test was conducted in male and female mice with the methanol extract of O. corniculata in accordance with Organisation for Economic Co-operation and Development (OECD) guideline 425. No signs of toxicity, mortality, and behavioral changes were observed following administration of 2000Â mg/kg b. w. The extract was, therefore, reported safe up to 2000Â mg/kg b. w. [35, 65]. OECD guidelines 423 and 425 were followed to test the acute toxicity of the ethanolic extract, and the animals survived at 2000Â mg/kg body weight, demonstrating the safety of the extract up to this dose [43, 46, 63].
3 Conclusion
Oxalis corniculata is a promising plant for future research as it combines traditional ethnomedicinal knowledge with modern scientific findings. The traditional use of the is supported by scientific evidence of its pharmacological activities. Organic solvent-based extraction techniques are widely used and well-documented in the literature for extracting bioactive compounds from medicinal plants. The diverse range of solvent polarities available enhances the selectivity and efficiency of compound separation, enabling the extraction of a wide variety of compounds such as saponins, phenolic compounds, flavonoids, and alkaloids from plants. O. corniculata methanol extract was found to have significant potency over ethanol, water, and the other solvents listed in Table 1 in a range of pharmacological activities, suggesting that they are potential candidates for additional investigations in the field of pharmaceutical research and drug discovery.
There is considerable potential for future research into the pharmacological activities of this plant, particularly for the elucidation of its mechanisms of action. This medicinal plant has the potential to become an important source of herbal medicines for the pharmaceutical industry. Future studies should aim to elucidate the mechanisms of action of key phytochemicals, conduct rigorous clinical trials to confirm traditional claims, explore potential synergistic effects of compounds, and develop standardized formulations for therapeutic use. As research on O. corniculata continues, it is essential to use multidisciplinary approaches and promote collaborative projects to fully harness the medicinal properties of this plant for modern healthcare. By combining expertise from different scientific disciplines and fostering partnerships between research institutions and industry, we can maximize the therapeutic potential of O. corniculata and ensure its safe and effective integration into modern medicine.
Availability of data and materials
Not applicable.
Abbreviations
- µg:
-
Microgram
- mL:
-
Milliliter
- mg:
-
Milligrams
- b.w.:
-
Body weight
- MDR:
-
Multi-drug resistant
- HPV-18:
-
Human Papillomavirus-18
- CCl4:
-
Carbon tetrachloride
- MPTP:
-
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- AST:
-
Aspartate aminotransferase
- ALT:
-
Alanine aminotransferase
- ALP:
-
Alkaline phosphatase
- TAA:
-
Thioacetamide
- TP53:
-
Tumor protein p53
- AKT1:
-
AKT serine/threonine kinase 1
- ALB:
-
Serum albumin protein
- IL6:
-
Interleukin 6
- STZ:
-
Streptozotocin
- ACE:
-
Angiotensin converting enzymes
- IUPAC:
-
International Union of Pure and Applied Chemistry
- CID:
-
Compound ID number
- mM:
-
Millimole
- LPS:
-
Lipopolysaccharide
- µM:
-
Micromole
- PI3K:
-
Phosphoinositide 3-kinases
- NF-κB:
-
Nuclear factor kappa-light-chain-enhancer of activated B cells
- Bcl-2:
-
B-cell lymphoma 2
- MMP-2/9:
-
Matrix metalloproteinases-2/9
- ER:
-
Endoplasmic reticulum
- MAPK:
-
Mitogen-activated protein kinase
- ROS:
-
Reactive oxygen species
- OECD:
-
Organisation for Economic Co-operation and Development
- HPLC:
-
High performance liquid chromatography
References
Shamso EM, Draz A, Hosni HA, Hussein SR (2022) Taxonomic revision of genus Oxalis L. (Oxalidaceae) in the flora of Egypt. Taeckholmia 41:56–69. https://doi.org/10.21608/TAEC.2022.118726.1036
Miller TW, Libbey CR, Maupin BG (2013) Evaluation of organic amendments and flaming for weed control in matted-row strawberry. HortScience 48:304–310. https://doi.org/10.21273/HORTSCI.48.3.304
Nuernberg-Silva A, Phytotaxa PF (2021) Taxonomic revision and morphological delimitation of Oxalis sect. Ripariae (Oxalidaceae). Phytotaxa 529:125–159
Hoshino Y, Hoshino M, Yoshioka K, Washio T, Nakamura M, Maki M, Dohzono I (2022) The effects of inbreeding depression and pollinator visitation on the maintenance of herkogamy in Oxalis corniculata, a species derived from a heterostylous ancestor. Plant Species Biol 37:349–360. https://doi.org/10.1111/1442-1984.12387
Mekap SK, Mishra SK, Panda PK, Panda SS, Sarangi DK (2022) A systematic review on Oxalis corniculata Linn. a crop field weed with promising pharmacological activities. Asian J Pharm Clin Res 15:4–8. https://doi.org/10.22159/AJPCR.2022.V15I8.45017
Ren L, Guan K, Tan M, Yang J, Wang G (2023) Description of four new species, two new records, and mitochondrial COI gene of eriophyoid mites from Nanning, China (Acari: Eriophyoidea). Syst Appl Acarol (SAA) 28:1195–1223. https://doi.org/10.11158/SAA.28.7.2
Groom QJ, Van Der Straeten J, Hoste I (2019) The origin of Oxalis corniculata L. PeerJ. https://doi.org/10.7717/PEERJ.6384
Kunte K, S.S.P.R. (Chief E. Butterflies of India, v. 4.18. Indian Foundation for Butterflies. https://www.ifoundbutterflies.org/pseudozizeeria-maha. Accessed 14 Dec 2023
Van der Straeten J, Groom Q (2018) A bibliography of the medicinal uses of Oxalis corniculata. Zenodo. https://doi.org/10.5281/ZENODO.1254000
Tibuhwa DD (2017) Antioxidant potentialities and antiradical activities of Oxalis corniculata Linn from Tanzania. J Appl Biosci 116:11590–11600. https://doi.org/10.4314/JAB.V116I1.7
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J 2013:16. https://doi.org/10.1155/2013/162750
Hamzah H, Siregar KAAK, Nurwijayanto A, Wahyuningrum R, Sari S (2021) Effectiveness of Oxalis corniculata L. ethanol extract against mono-species of biofilm Staphylococcus aureus. Borneo J Pharm 4:184–191. https://doi.org/10.33084/BJOP.V4I3.2418
Tibuhwa DD (2016) Oxalis corniculata L. in Tanzania: traditional use, cytotoxicity and antimicrobial activities. J Appl Biosci 105:10055–10063. https://doi.org/10.4314/jab.v105i1.2
Al-Qalhati IRS, Waly MI, Al-Subhi L, Al-Attabi Mostafa Z, Waly I (2021) Anti-diabetic potential properties of two edible Omani wild plants (Pteropyrum scoparium and Oxalis corniculata). J Agric Mar Sci [JAMS] 26:56–63. https://doi.org/10.53541/JAMS.VOL26ISS2PP56-63
Pathak SK, Kumar J (2018) Studies on morphological and quantitative characters of different species of Oxalis growing in Ranchi, Jharkhand. J Nat Prod Resour 04:160–161. https://doi.org/10.30799/JNPR.055.18040102
Fukano Y, Yamori W, Misu H, Sato MP, Shirasawa K, Tachiki Y, Uchida K (2023) From green to red: urban heat stress drives leaf color evolution. Sci Adv 9:eabq3542. https://doi.org/10.1126/SCIADV.ABQ3542/SUPPL_FILE/SCIADV.ABQ3542_TABLES_S1_TO_S4.ZIP
Sakauchi K, Taira W, Toki M, Tsuhako M, Umetsu K, Otaki JM (2021) Nutrient imbalance of the host plant for larvae of the pale grass blue butterfly may mediate the field effect of low-dose radiation exposure in fukushima: dose-dependent changes in the sodium content. Insects 12:149. https://doi.org/10.3390/INSECTS12020149
Benvenuti S (2007) Weed seed movement and dispersal strategies in the agricultural environment. Weed Biol Manag 7:141–157. https://doi.org/10.1111/J.1445-6664.2007.00249.X
El-Ghani MA, Bornkamm R, El-Sawaf N, Turky H (2015) Heterogeneity of soil and vegetation in the urban habitats of new industrial cities in the desert landscape of Egypt. Not Sci Biol 7:26–36. https://doi.org/10.15835/NSB719433
Naqinezhad A, De Lombaerde E, Gholizadeh H, Wasof S, Perring MP, Meeussen C, De Frenne P, Verheyen K (2022) The combined effects of climate and canopy cover changes on understorey plants of the Hyrcanian forest biodiversity hotspot in Northern Iran. Glob Change Biol 28:1103–1118. https://doi.org/10.1111/GCB.15946
Li J, Zhao T, Chen L, Chen H, Luo D, Chen C, Miao Y, Liu D (2022) Artemisia argyi allelopathy: a generalist compromises hormone balance, element absorption, and photosynthesis of receptor plants. BMC Plant Biol 22:1–17. https://doi.org/10.1186/S12870-022-03757-9/FIGURES/7
Li J, Chen L, Chen Q, Miao Y, Peng Z, Huang B, Guo L, Liu D, Du H (2021) Allelopathic effect of Artemisia argyi on the germination and growth of various weeds. Sci Rep 11:1–15. https://doi.org/10.1038/s41598-021-83752-6
Hayasaka D, Akasaka M, Miyauchi D, Box EO, Uchida T (2012) Qualitative variation in roadside weed vegetation along an urban-rural road gradient. Flora Morphol Distrib Funct Ecol Plants 207:126–132. https://doi.org/10.1016/J.FLORA.2011.11.005
Ministry of Ayush Government of India (2001) The ayurvedic pharmacopoeia of India part-I volume-III; Delhi
FRLHT Indian Medicinal Plants Database. http://www.medicinalplants.in/searchpage/showdetails/xplant_id/0ef91fd7704967eb83c9addd59ecd7ed. Accessed 15 Nov 2022
Badwaik H, Singh K, Thakur D, Giri K, Tripathi DK (2011) The botany, chemistry, pharmacological and therapeutic application of Oxalis corniculata Linn—a review. Int J Phytomed 3:1–08
Gudasi S, Gharge S, Koli R, Patil K (2023) Antioxidant properties and cytotoxic effects of Oxalis corniculata on human hepatocarcinoma (Hep-G2) cell line: an in vitro and in silico evaluation. Future J Pharm Sci 9:1–13. https://doi.org/10.1186/S43094-023-00476-2
Sarma G, Das S (2017) Hypoglycaemic action of ethanolic extract of leaves of Oxalis corniculata L. on normal and alloxan-induced diabetic albino rats. J Evid Based Med Healthc 4:4755–4761. https://doi.org/10.18410/JEBMH/2017/949
Begum S, Hussain S, Mehmood A, Ahmad KS, Hamid A (2018) Harnessing the potential of medicinal plants used for the treatment of diabetes in rural areas of Azad Jammu and Kashmir, Pakistan. Appl Ecol Environ Res 16:6549–6566. https://doi.org/10.15666/AEER/1605_65496566
Silalahi M (2022) Utilization of Oxalis corniculata Linn as a traditional medicine and its bioactivity. Magna Sci Adv Res Rev 5:027–033. https://doi.org/10.30574/MSARR.2022.5.2.0052
Bonna I, Afroz M, Sultana S, Alam S (2017) Comparative karyotype and RAPD analysis of four Oxalis L. species. Cytologia 82:527–533. https://doi.org/10.1508/cytologia.82.527
Noor N, Satapathy KB (2023) Leafy vegetable diversity and their ethnomedicinal uses against gastrointestinal disorders in the Balasore district of Odisha, India. J Appl Biol Biotechnol 11:259–267. https://doi.org/10.7324/JABB.2023.69250
Singh K, Gambhir L (2017) Antimicrobial effects of leaf extracts from Oxalis corymbosa against pathogenic bacterial and fungal isolates. WJPR 6:1267–1278. https://doi.org/10.20959/wjpr20177-8830
Manna D, Dutta PK, Achari B, Lohia A (2010) A novel galacto-glycerolipid from Oxalis corniculata kills entamoeba histolytica and giardia lamblia. Antimicrob Agents Chemother 54:4825–4832. https://doi.org/10.1128/AAC.00546-10/SUPPL_FILE/SUPPLEMENTARY_TABLE_1.PDF
Sakat SS, Tupe P, Juvekar A (2012) Gastroprotective effect of Oxalis corniculata (whole plant) on experimentally induced gastric ulceration in wistar rats. Indian J Pharm Sci 74:48–53. https://doi.org/10.4103/0250-474X.102543
Popay I (2022) Oxalis corniculata (creeping Woodsorrel). CABI compendium. https://doi.org/10.1079/CABICOMPENDIUM.38154
Sharangouda K, Patil SB (2007) Antiimplantation and abortifacient activities of Oxalis corniculata in albino rats. Niger J Nat Prod Med 11:58–60. https://doi.org/10.4314/NJNPM.V11I1.11883
Mei-Xian G, Yan-Shuang W, Gui-Rong S, Lei S (2014) Anti-inflammatory and analgesic effects of Oxalis corniculata L. on acute peritonitis in mice. J Dali Univ 13:6
Venkateswaran V, Shanmuga Sudaram R, Sambathkumar R (2017) Evaluation of analgesic and antipyretic activity of ethanol extract of Oxalis corniculata Linn. Int J Chem Pharm Sci 8:30–34
Dighe SB, Kuchekar BS, Wankhede SB (2012) Pharmacological evaluation of Oxalis corniculata Linn for anthelmintic activity. Res J Pharmacol Pharmacodyn 4:1–4
Gholipour AR, Jafari L, Ramezanpour M, Evazalipour M, Chavoshi M, Yousefbeyk F, Moghaddam SJK, Kooshali MHY, Ramezanpour N, Daei P et al (2022) Apoptosis effects of Oxalis corniculata L. extract on human MCF-7 breast cancer cell line. Galen Med J 11:e2484–e2484. https://doi.org/10.31661/GMJ.V11I.2484
Kathiriya A, Das K, Kumar E, Mathai K (2010) Evaluation of antitumor and antioxidant activity of Oxalis corniculata Linn. against ehrlich ascites carcinoma on mice. Iran J Cancer Prev 3:157–165
Dutta A, Lahkar M, Handique C (2017) Evaluation of antidiabetic activity of Oxalis corniculata in streptozotocin induced diabetic rats. Int J Basic Clin Pharmacol 5:2178–2183. https://doi.org/10.18203/2319-2003.IJBCP20163258
Watcho P, Nkouathio E, Nguelefack TB, Wansi SL, Kamanyi A (2005) Antidiarrhoeal activity of aqueous and methanolic extracts of Oxalis corniculata klotzsch in rats. Cameroon J Exp Biol 1:46–49. https://doi.org/10.4314/CAJEB.V1I1.37933
Mukherjee S, Koley H, Barman S, Mitra S, Datta S, Ghosh S, Paul D, Dhar P (2013) Oxalis corniculata (Oxalidaceae) leaf extract exerts in vitro antimicrobial and in vivo anticolonizing activities against Shigella dysenteriae 1 (NT4907) and Shigella flexneri 2a (2457T) in induced diarrhea in suckling mice. J Med Food 16:801–809. https://doi.org/10.1089/jmf.2012.2710
Dutta A, Handique C, Lahkar M (2015) Evaluation of anti-inflammatory activity of Oxalis corniculata in experimentally induced inflammatory bowel disease in rats. Int J Basic Clin Pharmacol 4:744–748. https://doi.org/10.18203/2319-2003.IJBCP20150383
Dighe SB, Kuchekar BS, Wankhede SB, Santosh M, Dighe Head B (2016) Analgesic and anti-inflammatory activity of β-sitosterol isolated from leaves of Oxalis corniculata. Int J Pharmacol Res 6:109–113. https://doi.org/10.7439/ijpr
Misrahanum M, Almunawwarah SD, Helwati H, Maysarah H, Sadli S (2021) Antimicrobial activity Jangjingki (Oxalis corniculata L.) against the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. J Pharm Sci 4:1–11. https://doi.org/10.36490/journal-jps.com.v4i1.58
Mukherjee S, Pal S, Chakraborty R, Koley H, Dhar P (2018) Biochemical assessment of extract from Oxalis corniculata L.: its role in food preservation, antimicrobial and antioxidative paradigms using in situ and in vitro models
Rahman M, Khan M (2010) Anti-bacterial evaluation and minimum inhibitory concentration analysis of Oxalis corniculata and Ocimum santum against bacterial pathogens. Biotechnology. https://doi.org/10.3923/biotech.2010.533.536
Manandhar S, Luitel S, Dahal RK (2019) In vitro antimicrobial activity of some medicinal plants against human pathogenic bacteria. J Trop Med. https://doi.org/10.1155/2019/1895340
Rehman A, Rehman A, Ahmad I (2015) Antibacterial, antifungal, and insecticidal potentials of Oxalis corniculata and its isolated compounds. Int J Anal Chem. https://doi.org/10.1155/2015/842468
Johnson BL, Arakareddy B, Sam KK (2020) Formulation of an anti-bacterial cream from plant Oxalis corniculata and its evaluation. Int J Curr Pharm Res. https://doi.org/10.22159/IJCPR.2020V12I5.39763
Badrul Alam M, Sarowar Hossain M, Chowdhury NS, Ehsanul Haque Mazumder M, Ekramul Haque M, Islam A (2011) In vitro and in vivo antioxidant and toxicity evaluation of different fractions of Oxalis corniculata Linn. J Pharmacol Toxicol 6:337–348. https://doi.org/10.3923/JPT.2011.337.348
Juvekar A, Sakat S, Wankhede S, Juvekar M, Gambhire M (2009) Evaluation of antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata. Planta Med 75:PJ78. https://doi.org/10.1055/S-0029-1234983
Ahmed D, Zara S, Baig H (2013) In vitro analysis of antioxidant activities of Oxalis corniculata Linn. fractions in various solvents. Afr J Tradit Complement Altern Med 10:158–165. https://doi.org/10.4314/AJTCAM.V10I1.21
Borah A, Yadav R (2012) Evaluation of antioxidant activity of different solvent extracts of Oxalis Corniculata L. J Pharm Res 5:91–93
Gao T, Hu W, Zhang Z, Tang Z, Chen Y, Zhang Z, Yuan S, Chen T, Huang Y, Feng S et al (2022) An acidic polysaccharide from Oxalis corniculata L. and the preliminary study on its antioxidant activity. J Food Biochem 46:e14235. https://doi.org/10.1111/JFBC.14235
Khan MR, Marium A, Shabbir M, Saeed N, Bokhari J (2012) Antioxidant and hepatoprotective effects of Oxalis corniculata against carbon tetrachloride (CCl4) induced injuries in rat. Afr J Pharm Pharmacol 6:2255–2267. https://doi.org/10.5897/AJPP11.370
Abhilash PA, Nisha P, Prathapan A, Nampoothiri SV, Lijo Cherian O, Sunitha TK, Raghu KG (2011) Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction. Exp Toxicol Pathol 63:535–540. https://doi.org/10.1016/J.ETP.2010.04.004
Khan MR, Zehra H (2013) Amelioration of CCl4-induced nephrotoxicity by Oxalis corniculata in rat. Exp Toxicol Pathol 65:327–334. https://doi.org/10.1016/J.ETP.2011.11.007
Gupta G, Kazmi I, Afzal M, Rahman M, Anwar F (2012) Anxiolytic effect of Oxalis corniculata (Oxalidaceae) in mice. Asian Pac J Trop Dis 2:S837–S840. https://doi.org/10.1016/S2222-1808(12)60275-8
Sampath ST, Lahkar M, Kumars P, Sampath S (2011) Anxiolytic effect of ethanolic extract of Oxalis corniculata L. in mice. Int J Pharm Biol Sci 2:281–290
Moyeenudin HM, Vijayalakshmi S (2019) The antihypertensive effect from aqueous extract of Oxalis corniculata by in vitro antihypertensive activity assay. Res J Pharm Technol 12:2981–2986. https://doi.org/10.5958/0974-360X.2019.00504.3
Das M, Gohain K (2018) Study of neuroprotective activity of methanolic extract of Oxalis corniculata Linn on animal models of depression. Int J Eng Sci Res Technol 7:396–405. https://doi.org/10.5281/zenodo.1297373
Jadhav AG, Anil JG, Mrutyunjay PB, Sachin NB, Vidya Sagar G (2010) Hepatoprotective activity of Oxalis corniculata leaves against carbon tetrachloride induced hepatotoxicity in female albino wistar rats. Res J Pharmacogn Phytochem 2:136–139
Das K, Kathiriya AK, Kumar EP, Benson MK, Einstein JW (2012) Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats. Rev Bras 22:412–417. https://doi.org/10.1590/S0102-695X2011005000189
Das P, Kumar K, Nambiraj A, Awasthi R, Dua K, Malipeddi H (2018) Antibacterial and in vitro growth inhibition study of struvite urinary stones using Oxalis corniculata Linn. leaf extract and its biofabricated silver nanoparticles. Recent Pat Drug Deliv Formul 12:170–178. https://doi.org/10.2174/1872211312666180723160624
Aruna K, Rajeswari PDR, Sankar SR (2017) The effect of Oxalis corniculata extract against the behavioral changes induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) in mice. J Appl Pharm Sci 7:148–153. https://doi.org/10.7324/JAPS.2017.70324
Taranalli AD, Tipare SV, Kumar S, Torgal SS (2004) Wound healing activity of Oxalis corniculata whole plant extract in rats. Indian J Pharm Sci 66:444
van Ngo T, Scarlett CJ, Bowyer MC, Ngo PD, van Vuong Q (2017) Impact of different extraction solvents on bioactive compounds and antioxidant capacity from the root of Salacia chinensis L. J Food Qual. https://doi.org/10.1155/2017/9305047
Silvestre M, Gonzalez-Pastor R, Carrera-Pacheco SE, Zúñiga-Miranda J, RodrÃguez-Pólit C, Mayorga-Ramos A, Guamán LP, Barba-Ostria C (2023) Current landscape of methods to evaluate antimicrobial activity of natural extracts. Molecules 28:1068. https://doi.org/10.3390/MOLECULES28031068
Salaria D, Rolta R, Mehta J, Awofisayo O, Fadare OA, Kaur B, Kumar B, da Costa RA, Chandel SR, Kaushik N et al (2022) Phytoconstituents of traditional Himalayan herbs as potential inhibitors of human papillomavirus (HPV-18) for cervical cancer treatment: an in silico approach. PLoS ONE 17:e0265420. https://doi.org/10.1371/JOURNAL.PONE.0265420
Omara T, Kiprop AK, Ramkat RC, Cherutoi J, Kagoya S, Moraa Nyangena D, Azeze Tebo T, Nteziyaremye P, Nyambura Karanja L, Jepchirchir A et al (2020) Medicinal plants used in traditional management of cancer in Uganda: a review of ethnobotanical surveys, phytochemistry, and anticancer studies. Evid Based Complement Altern Med. https://doi.org/10.1155/2020/3529081
Ambu G, Chaudhary RP, Mariotti M, Cornara L (2020) Traditional uses of medicinal plants by ethnic people in the Kavrepalanchok District, Central Nepal. Plants 9:759. https://doi.org/10.3390/PLANTS9060759
Norfarizan-Hanoon NA, Nurraihana H, Hasmah A, Wan Rosli WI (2017) Phytochemical and antioxidant potential of four traditional Malaysian medicinal plants. J Trop Resour Sustain Sci (JTRSS) 5:9–14. https://doi.org/10.47253/JTRSS.V5I1.648
Saracila M, Panaite TD, Untea AE, Varzaru I (2022) Effect of dietary supplementation of some antioxidant combinations on nutrient digestibility in heat-stressed broilers. Archiva Zootechnica 25:116–129. https://doi.org/10.2478/AZIBNA-2022-0008
Handique JG, Boruah MP, Kalita D (2012) Antioxidant activities and total phenolic and flavonoid contents in three indigenous medicinal vegetables of north-east India. Nat Prod Commun 7:1021–1023
Hossain S, Islam J, Ahmed F, Hossain A, Abdul M, Siddiki K, Moazzem Hossen SM (2015) Free radical scavenging activity of six medicinal plants of Bangladesh: a potential source of natural antioxidant. J Appl Pharm 7:96–104
Pandey K, Pokhrel S (2022) Phytochemical screening and biological activities of Oxalis corniculata leaves of Sindhupalchowk District, Nepal. BIBECHANA 19:27–33. https://doi.org/10.3126/BIBECHANA.V19I1-2.46094
Fathima SN, Vasudeva Murthy S (2018) Current pharmacological status of cardioprotective plants against isoproterenol induced myocardial infarction. Asian J Pharm Clin Res 11:17–27. https://doi.org/10.22159/AJPCR.2018.V11I4.24158
Gaire BP, Subedi L (2011) Medicinal plant diversity and their pharmacological aspects of Nepal Himalayas. Pharmacogn J 3:6–17. https://doi.org/10.5530/PJ.2011.25.2
Hennia A, Miguel MG, Nemmiche S (2018) Antioxidant activity of Myrtus communis L. and Myrtus Nivellei Batt. & Trab. extracts: a brief review. Medicines 5:89. https://doi.org/10.3390/MEDICINES5030089
Rahman IU, Afzal A, Iqbal Z, Hart R, Abd Allah EF, Hashem A, Alsayed MF, Ijaz F, Ali N, Shah M et al (2019) Herbal teas and drinks: folk medicine of the Manoor Valley, Lesser Himalaya, Pakistan. Plants 8:581. https://doi.org/10.3390/PLANTS8120581
Ding Q, Huang X, Yang X, Zhang M, Qin P, Wu H, Wang X (2021) Study of the mechanism of Oxalis corniculata (L.) in the treatment of hepatitis based on network pharmacology. IOP Conf Ser Earth Environ Sci 714:032021. https://doi.org/10.1088/1755-1315/714/3/032021
Wong MKS (2016) Angiotensin converting enzymes. In: Handbook of hormones: comparative endocrinology for basic and clinical research, pp 263-e29D-4. https://doi.org/10.1016/B978-0-12-801028-0.00254-3
Yang J, Guo J, Yuan J (2008) In vitro antioxidant properties of rutin. LWT Food Sci Technol 41:1060–1066. https://doi.org/10.1016/J.LWT.2007.06.010
Pugazhendhi D, Pope GS, Darbre PD (2005) Oestrogenic activity of P-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines. J Appl Toxicol 25:301–309. https://doi.org/10.1002/JAT.1066
Graf E (1992) Antioxidant potential of ferulic acid. Free Radic Biol Med 13:435–448. https://doi.org/10.1016/0891-5849(92)90184-I
Prasad Pandey B, Prakash Pradhan S, Adhikari K (2020) LC-ESI-QTOF-MS for the profiling of the metabolites and in vitro enzymes inhibition activity of Bryophyllum pinnatum and Oxalis corniculata collected from Ramechhap District of Nepal. Chem Biodivers 17:e2000155. https://doi.org/10.1002/CBDV.202000155
Anilkumar K, Reddy GV, Azad R, Sastry Yarla N, Dharmapuri G, Srivastava A, Kamal MA, Pallu R (2017) Evaluation of anti-inflammatory properties of isoorientin isolated from tubers of Pueraria tuberosa. Oxid Med Cell Longev. https://doi.org/10.1155/2017/5498054
Srivastava A, Dadheech N, Vakani M, Gupta S (2018) Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in streptozotocin treated BALB/c mice. Biomed Pharmacother 100:221–225. https://doi.org/10.1016/J.BIOPHA.2018.01.096
Mizokami H, Tomita-Yokotani K, Yoshitama K (2008) Flavonoids in the leaves of Oxalis corniculata and sequestration of the flavonoids in the wing scales of the pale grass blue butterfly, Pseudozizeeria maha. J Plant Res 121:133–136. https://doi.org/10.1007/s10265-007-0132-x
Bhardwaj M, Cho HJ, Paul S, Jakhar R, Khan I, Lee SJ, Kim BY, Krishnan M, Khaket TP, Lee HG et al (2018) Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. Oncotarget 9:3278. https://doi.org/10.18632/ONCOTARGET.22890
Baniahmad B, Safaeian L, Vaseghi G, Rabbani M, Mohammadi B (2020) Cardioprotective effect of vanillic acid against doxorubicin-induced cardiotoxicity in rat. Res Pharm Sci 15:87. https://doi.org/10.4103/1735-5362.278718
Cui H, Yuan J, Du X, Wang M, Yue L, Liu J (2015) Ethyl gallate suppresses proliferation and invasion in human breast cancer cells via Akt-NF-ΚB signaling. Oncol Rep 33:1284–1290. https://doi.org/10.3892/OR.2014.3682/HTML
Lv SX, Qiao X (2018) Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. Biochem Biophys Res Commun 496:1047–1054. https://doi.org/10.1016/J.BBRC.2018.01.111
Draz AA, Kawashty SA, Shamso EM, Hosni HA, Hussein SR (2022) Chemical profiling of Oxalis species growing wild in Egypt using HRLC/MS spectrometry. Int J Second Metab 9:426–439. https://doi.org/10.21448/ijsm.1110807
Zhang G, Dong J, Lu L, Liu Y, Hu D, Wu Y, Zhao A, Xu H (2023) Acacetin exerts antitumor effects on gastric cancer by targeting EGFR. Front Pharmacol 14:1121643. https://doi.org/10.3389/FPHAR.2023.1121643/BIBTEX
Sakauchi K, Taira W, Otaki JM (2022) Metabolomic profiles of the creeping wood sorrel Oxalis corniculata in radioactively contaminated fields in fukushima: dose-dependent changes in key metabolites. Life. https://doi.org/10.3390/life12010115
Ibrahim M, Hussain I, Imran M, Hussain N, Hussain A, Mahboob T (2013) Corniculatin A, a new flavonoidal glucoside from Oxalis corniculata. Rev Bras 23:630–634. https://doi.org/10.1590/S0102-695X2013005000059
Chen HI, Hu WS, Hung MY, Ou HC, Huang SH, Hsu PT, Day CH, Lin KH, Viswanadha VP, Kuo WW et al (2020) Protective effects of luteolin against oxidative stress and mitochondrial dysfunction in endothelial cells. Nutr Metab Cardiovasc Dis 30:1032–1043. https://doi.org/10.1016/J.NUMECD.2020.02.014
Perez-Vizcaino F, Duarte J, Jimenez R, Santos-Buelga C, Osuna A (2009) Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep 61:67–75. https://doi.org/10.1016/S1734-1140(09)70008-8/METRICS
Gupta R, Sharma AK, Dobhal MP, Sharma MC, Gupta RS (2011) Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia. J Diabetes 3:29–37. https://doi.org/10.1111/J.1753-0407.2010.00107.X
Kiran KS, Kameshwar VH, Kumar Munakudu-Nagaraju K, Nagalambika P, Kavitha R, Karthick A, GuruKumar D, Swamy SN, Krishna KL, Kumar JR (2023) Diosmin: a Daboia russelii venom PLA2s inhibitor- purified, and characterized from Oxalis corniculata L medicinal plant. J Ethnopharmacol. https://doi.org/10.1016/J.JEP.2023.116977
Eraslan G, Sarıca ZS, Bayram LÇ, Tekeli MY, Kanbur M, Karabacak M (2017) The effects of Diosmin on aflatoxin-induced liver and kidney damage. Environ Sci Pollut Res 24:27931–27941. https://doi.org/10.1007/S11356-017-0232-7/METRICS
Acknowledgements
Authors are thankful to CSIR-IMTECH for consistent support and motivation. This is CSIR-IMTECH Communication Number 033/2023.
Funding
RB and Priyanka are funded by CSIR-SRF. NK lab is supported by CSIR-IMTECH research grants.
Author information
Authors and Affiliations
Contributions
RB was responsible for data curation, writing the original draft, and methodology. PP was responsible for reviewing, editing, and data curation. PB was responsible for data curation and methodology. NK was responsible for editing the manuscript, conceptualization, reviewing, writing, and data curation.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
No competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Bharti, R., Priyanka, P., Bhargava, P. et al. Ethnopharmacology and therapeutic potentials of Oxalis corniculata: an in-depth study. Beni-Suef Univ J Basic Appl Sci 13, 81 (2024). https://doi.org/10.1186/s43088-024-00541-6
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s43088-024-00541-6