Articles

The alleviative efficacy of sildenafil and chrysin against zinc oxide nanoparticles-provoked hepatic and blood toxicity: role of MyD88/NF-κB1/TNF-α pathway

Zinc oxide nanoparticles are nanoparticles of metal oxide with semiconductor properties and proved many noxious effects on the mammalian cell. Sildenafil, a phosphodiesterase inhibitor, and chrysin, one of the...

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Empagliflozin versus Sitagliptin as add-on dual therapy in Egyptian patients with type 2 diabetes inadequately controlled with Metformin: a 12-week randomized, open-label, parallel-group trial

Diabetes is one of the world’s most widespread conditions, and diabetic patients are among the most likely to engage in fierce battles with this chronic disease. Which group should be added-on as a dual therap...

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Efficacy of polyherbal formulation along with standard care of treatment in early recovery of COVID-19 patients: a randomized placebo-controlled trial

The coronavirus disease-2019 (COVID-19) pandemic crisis has affected millions of people worldwide. The emergence of mutant strains one after the other, breakthrough infections post-vaccination and reinfection ...

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Hydrogen peroxide enhances transforming growth factor beta-2 induced epithelial–mesenchymal transition of ARPE-19 cells

In the pathophysiology of the retina, the epithelial–mesenchymal transition and oxidative stress play key roles. To find a relationship between oxidative stress and diabetic retinopathy or proliferative retino...

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A modified model for laser-cornea interaction following the ablation effect in the laser eye-surgery

Laser corneal reshaping is a successful treatment of many refraction disorders. However, some physical demonstrations for the laser interaction with cornea are not fully explained. In the current paper, we pre...

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Immunogenicity of extracellular proteins of Flavobacterium covae in Ictalurus punctatus

Columnaris disease, instigated by Gram-negative Flavobacterium covae (F. covae), is a dreadful disease of many different genera of freshwater fish with alarmingly high mortality rates. Ictalurus punctatus (I. pun...

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Polydatin nanoparticles attenuate oxidative stress and histopathological changes in streptozotocin model of diabetic nephropathy: targeting Nrf2/HO-1/NF-κβ signaling pathways

One of the most prevalent and serious side effects of diabetes mellitus is diabetic nephropathy, which is characterized by abnormalities in kidney structure that can occur before kidney function declines. Up t...

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Carbapenemase producing Enterobacterales clinical isolates from a tertiary care hospital in Egypt

Carbapenem resistant Enterobacterales (CRE) is on the rise globally, triggering a significant health threat and a substantial concern for infection control management. We aimed to detect and characterize carba...

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Immunohistochemical assessment of the potential behavior of glandular odontogenic cyst and inflammatory periodontal cyst using E-cadherin and N-cadherin

This study is done to evaluate the immunohistochemical expression of E-cadherin and N-cadherin in glandular odontogenic cysts (GOC), inflammatory periodontal (IPDL) cysts, and dental follicles (DF), and if the...

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Endothelium-dependent vasorelaxation effects of F5 fraction of Crinum amabile chloroform extract

Vascular dysfunction can lead to many health problems including hypertension and heart disease. The complexities of vascular dysfunction and vascular disorder-related diseases have prompted the search for many...

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A hybrid B-spline collocation technique for the Caputo time fractional nonlinear Burgers’ equation

This study proposes an efficient and stable technique based on new hybrid B-spline (HB-spline) functions for the numerical treatment of the Caputo time fractional nonlinear Burgers’ (TFNB) equation. The time d...

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Regulation of epithelial-mesenchymal transition in retinal pigment epithelium and its associated cellular signaling cascades: an updated review

The epithelial-mesenchymal transition (EMT) affects the retinal pigment epithelium's natural homeostasis. According to observations from around the world, numerous oculopathies, including proliferative vitreor...

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The modified homotopy perturbation method and its application to the dynamics of price evolution in Caputo-fractional order Black Scholes model

Following a financial loss in trades due to lack of risk management in previous models from market practitioners, Fisher Black and Myron Scholes visited the academic setting and were able to mathematically dev...

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Correction: Efficacy of threshold inspiratory muscle trainer versus diaphragmatic plus pursed lip breathing in occupational COPD

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Characterization and optimization of clove oil-loaded nanomicelles for the possible topical use of bacterial infection-led atopic dermatitis

Atopic dermatitis is an abnormal skin condition that impacts a significant number of people in the US, with an estimated 9.6 million children and 16.5 million adults being affected by it. The study aimed to ch...

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A prototype variable corresponding to the proportion of ischemia for the comparison between robotic and open partial nephrectomy: a meta-analysis accompanied by sensitivity analysis

The primary objective of this study involves the formulation of a novel variable, derived from initial data related to ischemia duration and operative time in partial nephrectomies. The aim was to determine th...

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Study of Cosavirus, Salivirus, and Bufavirus viruses in children with acute gastroenteritis

Acute gastroenteritis (AGE) in children represents a health problem. Besides common enteric viruses such as rotavirus and adenovirus, new viruses such as cosavirus, salivirus, and bufavirus may be associated w...

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The rising burden of chronic kidney diseases in patients with diabetes

The prevalence of chronic kidney diseases (CKD) is higher in patients with diabetes. The American diabetes association (ADA) provides components of diabetes care, treatments, and guidelines to diagnose diabeti...

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Artificial intelligence in diagnosis and management of Huntington’s disease

Huntington’s disease is one of the rare neurodegenerative diseases caused because of genetic mutation of the Huntingtin gene. The major hallmarks of the condition include motor impairment, cognitive decline, a...

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Hydromagnetic flow of micropolar nanofluids with co-effects of thermal radiation and chemical reaction over an inclined permeable stretching surface

Many investigations have been conducted by researchers across the globe to examine the behavior of fluids with respect to the influence of some constituent parameters and novel results have been obtained. Howe...

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Evaluation of the therapeutic potentials of extract fractions of Vernonia calvoana on streptozotocin-induced diabetic rats: approach through in silico, in vitro and in vivo studies

Diabetes is a serious metabolic disorder and many medicinal plants are used in traditional medicine to manage it. This study aimed to evaluate the therapeutic effects of Vernonia calvoana (V. calvoana) extract fr...

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The effect of slope height and angle on the safety factor and modes of failure of 3D slopes analysis using limit equilibrium method

It is a well-known fact that the safety of slopes majorly depends on several factors such as geometry, soil properties. The safety factor might change significantly depending on the soil type and the slope’s s...

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Hybrid chitosan gold nanoparticles for photothermal therapy and enhanced cytotoxic action of 6-mercaptopurine on breast cancer cell line

One of the most popular anti-inflammatory and anti-leukemic medications is 6-mercaptopurine, along with its riboside derivatives. Because of their potent adverse effects and limited biological half-life, they ...

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Chemical characteristics and anti-Escherichia coli mechanism of water-soluble extracts from yeast cell walls

Antimicrobial resistance is a threat to global public health and requires the development of new antibiotic alternatives to treat bacterial infection. Infection with Escherichia coli (E. coli) is the most common ...

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Infertility diagnosis and management

One of the most stressful problems for married couples is infertility, which is a widespread health issue. It has been defined as a profound life-changing problem that comes with severe psychological stress de...

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Recent trends in Helicobacter pylori management: harnessing the power of AI and other advanced approaches

Helicobacter pylori (H. pylori) is a bacterial infection that is prevalent and affects more than half of the world's population, causing stomach disorders such as gastritis, peptic ulcer disease, and gastric canc...

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Characterizing excision repair cross-complementing family genes as drug resistance biomarkers in breast cancer

Excision repair cross-complementing (ERCC) genes are important regulators of DNA repair processes, the aberrant expression of which may lead to treatment failures of breast cancer. The prognostic significance ...

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Root coverage surgeries using modified tunneling technique of xenogenic collagen matrix versus autologous connective tissue graft as a treatment of Miller class II gingival recession (RCT study)

Recently, there is increased demand for periodontal plastic surgery and development of new surgical approaches for aesthetic purposes. Gingival recession (GR) is the exposure of the root surfaces leading to es...

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Role of xylo-oligosaccharides in relieving complications accompanied to carbimazole drug administrated with 1% saline in female Wistar rats

Ameliorating the complications of pharmaceutical drugs by natural compounds or probiotics is now a medical strategy. The anti-thyroid drug carbimazole was reported to cause some complications as liver and kidn...

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Analytical solution of thermal effect on unsteady visco-elastic dusty fluid between two parallel plates in the presence of different pressure gradients

Thermal diffusion of dusty fluids has valuable interference in various fields, including waste-water treatment, oil transportation, and power plant pipes. Dusty fluids are used in lots of industrial fields as ...

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Pre-diabetes and diabetic neuropathy are associated with low serum levels of interleukin-9

Interleukin-9 (IL-9) is a cytokine that has recently been proposed to be associated with type 2 diabetes mellitus (T2DM) risk, but the role it plays in the development of pre-diabetes (PD) and diabetic neuropa...

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Enhancing rice resilience to drought by applying biochar–compost mixture in low-fertile sandy soil

Climate change alters modern drought episode patterns by making them longer, more frequent and more severe, in particular in arid and semi-arid agroecosystems. Amending soil properties and enhancing its fertil...

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Efficacy of threshold inspiratory muscle trainer versus diaphragmatic plus pursed lip breathing in occupational COPD

Smoking mainly induces COPD, but occupational threats play a significant role in the development of COPD. Previous studies concerning pulmonary rehabilitation mainly focus on COPD caused by smoking, but COPD i...

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Fabrication and functional attributes of nanotherapeutically engineered system for co-administration of adapalene and lycopene for enhanced acne management: an in vitro and in vivo investigation

Acne vulgaris is caused due to several different biological, environmental and specific pathological factors, resulting in secretion of unregulated amount of sebum by the sebaceous glands. Acne is thought to b...

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Neuroprotective compounds from marine invertebrates

Neuroinflammation is a key pathological feature of a wide variety of neurological disorders, including Parkinson’s, multiple sclerosis, Alzheimer’s, and Huntington’s disease. While current treatments for these...

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Exploring the morphological and genetic diversity of Egyptian basil landraces (Ocimum sp.) for future breeding strategies

Basil (Ocimum sp.) exhibits significant morphological and genetic diversity. This variation provides an opportunity to identify novel traits that can be used in breeding programs to improve the productivity, qual...

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Identification of possible SARS-CoV-2 main protease inhibitors: in silico molecular docking and dynamic simulation studies

COVID-19 was declared a pandemic by the World Health Organisation in 2020 after its outbreak in December 2019 in Wuhan, China. Since researchers have been working to develop specific drugs to cure COVID-19. CO...

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Long noncoding RNA (taurine upregulated gene 1) and micro RNA-377: emerging players in the development of metabolic syndrome among psoriasis patients

Psoriasis (PsO) is an immune-mediated dermatosis and systemic inflammatory condition that can affect the skin, joints, and other organs and tissues with a range of comorbidities. The activation of proinflammat...

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Effectiveness of ethyl acetate extract from Aspergillus flavipes AUMC 11390 culture filtrate on biological and physiological performance of the spiny bollworm, Earias insulana, (Boisd.) (Lepidoptera: Nolidae)

Spiny bollworm, Earias insulana is a serious cotton pest in Egypt. Besides the economic losses it caused, treatment with chemical insecticides has negative effects on human health and the environment, thus the de...

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Recent advances in solar photovoltaic materials and systems for energy storage applications: a review

In recent years, solar photovoltaic technology has experienced significant advances in both materials and systems, leading to improvements in efficiency, cost, and energy storage capacity. These advances have ...

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Integrated in vivo and in silico evaluation of sweet basil oil as a protective agent against cisplatin-induced neurotoxicity in mice

Cisplatin is a wide-ranging antineoplastic drug. Neurotoxicity is one of cisplatin’s side effects that restrict its usage. This study aimed to investigate the possible protective properties of sweet basil oil ...

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Gene polymorphism of FTO rs8050136 and CDKAL1 rs10946398 and their association with type 2 diabetes mellitus in the Egyptian patients

An extensive quest for genetic variables impacting the susceptibility for type 2 diabetes mellitus (T2DM) and other cardiometabolic disorders has been sparked by the global growth in the frequency of those wid...

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GC-MS analysis of honeybee products derived from medicinal plants

Honeybees provide a wealth of valuable natural products containing health-promoting bioactive compounds, including honey, bee bread, bee venom, bee pollen, propolis, and royal jelly. In the present study, we i...

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In ovo given sunset yellow adversely affects embryonic development of chick thymus and bursa Fabricii as evidenced by histological and enzyme histochemical findings

Sunset yellow (E110) has largely been used as food coloring agent. Complaints accumulated on E110 for possible detrimental effects on the immune functions such as allergenicity in the children. In this study, ...

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Phenotypic and genotypic characterization of carbapenem-resistant Gram-negative organisms, Beni-Suef, Egypt

Carbapenem-resistant Gram-negative organisms (CRGNO) are a growing threat. We aimed in our study to determine the genotype of carbapenemases at Beni-Suef University Hospital by using newly introduced lateral f...

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Curcumin-polyvinyl alcohol nano-composite enhances tolerance of Helianthus annuus L. against salinity stress

Nanotechnology is a promising technology in many fields including agriculture. So, this investigation aimed to study effect of curcumin (CUR) with polyvinyl alcohol (PVA) nano-compositeat 0, 20, 40 and 60 mg L⁻¹ ...

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Nutritional composition, antioxidant activity and gossypol level of Nazilli glandless cottonseed, cottonseed kernel and their cold-pressed meal

The study was conducted to determine the nutrient composition and gossypol levels of glandless cottonseed (GCS), glandless cottonseed kernel (GCSK) glandless cottonseed meal (GCSM) and cottonseed kernel meal (...

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Metabolomics-guided identification of compounds with antibacterial and antioxidant activities from Polygonatum sibiricum-derived endophytic fungi

Infections caused by multidrug resistant bacterial pathogens have been recognized as major global healthcare threat to medicinal, agricultural and pharmaceutical industries by World Health Organization. In thi...

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Thyroxine restores hippocampal neurogenesis and synaptogenesis in a male rat model of carbimazole-induced hypothyroidism: a histological study

Adult-onset hypothyroidism has a deleterious effect on hippocampal cognitive and memory functions. This study was performed to evaluate the possible therapeutic effect of thyroxine on hippocampus degeneration ...

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