Articles

Computer aided design of novel antibiotic drug candidate against multidrug resistant strains of Salmonella typhi from pyridine-substituted coumarins

The rising cases of resistance to existing antibiotics by Salmonella typhi, has made the development of novel drug candidates a necessity. In this study, a data set of antibacterial pyridine substituted coumarins...

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The association of p21, inhibin, and Tob-1 expression with the clinicopathological characteristics of benign and malignant colorectal lesions

Worldwide, colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer-related deaths. p21, inhibin, and Tob-1 are tumor suppressors that play a role in the development a...

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Overcoming Klebsiella pneumoniae antibiotic resistance: new insights into mechanisms and drug discovery

Due to antibiotic overuse, numerous organisms have evolved multidrug resistance, a global health crisis. Klebsiella pneumoniae (K. pneumoniae) causes respiratory, biliary, and urinary infections. It initially imp...

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Comparison of four DNA barcoding loci to distinguish between some Apiaceae family species

The Apiaceae family is among the most significant plant families because it contains both beneficial and poisonous plants. Due to their morphological similarity, these harmless and lethal species are frequently c...

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Proanthocyanidins supplemented diet alter anti-aging-markers and improved lifespan in Drosophila melanogaster model

It is unequivocally believed that phenolics and flavonoids from fruits and vegetables hold robust prevention potentials against age-related disease development through their abundant hydroxyl groups. This stud...

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Ultrasound-guided percutaneous nephrolithotomy versus conventional c-arm-guided percutaneous nephrolithotomy: a prospective randomized comparative study

Ultrasound guidance for renal access in percutaneous nephrolithotomy (PCNL) is a safe, effective, and low-cost procedure. The current study compared the safety and effectiveness of ultrasound-guided PCNL (US-P...

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Insecticidal activity and possible modes of action of secondary metabolites of some fungal strains and wild plants as natural pesticides against Spodoptera frugiperda

The fall armyworm (FAW), Spodoptera frugiperda, is an invasive and destructive pest to certain strategic crops, especially maize in Egypt. This research was conducted mainly to obtain secondary metabolites from s...

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Molecular characterization of the camel nasal botfly, Cephalopina titillator (Diptera: Oestridae)

Larval stages of the camel nasal botfly, Cephalopina titillator (Diptera: Oestridae), rank among the top obligate endoparasites causing nasopharyngeal myiasis. Such infestations have adverse effects on camel heal...

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Assessment of the protective and ameliorative impact of quercetin nanoparticles against neuronal damage induced in the hippocampus by acrolein

The most frequent kind of dementia in the senior population is Alzheimer's disease (AD). Antioxidant quercetin has a low bioavailability. The bioavailability of quercetin nanoparticles was demonstrated to be h...

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Phenolic-rich fraction of green tea attenuates histamine-mediated cardiopulmonary toxicity by inhibiting Cox-2/NF-κB signaling pathway and regulating oxidant/antioxidant balance

Histamine (HIS) has a substantial impact on the development of numerous allergic disorders including asthma. Antihistamines mostly target histamine receptor-1 alone, so it is not entirely effective in the trea...

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Use of agro-industrial bio-waste for the growth and production of a previously isolated Bacillus thuringiensis strain

Bacillus thuringiensis (Bt) is a widely used biopesticide. The bioinsecticide based on Bt is obtained by fermentation, but the substrates currently used for its production constitute ingredients of high commercia...

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Machine learning-driven optimization of enterprise resource planning (ERP) systems: a comprehensive review

In the dynamic and changing realm of technology and business operations, staying abreast of recent trends is paramount. This review evaluates the progress in the development of the integration of machine learn...

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Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

The lipid self-emulsifying system has been advanced as a promising delivery vehicle for improving the solubility and bioavailability of artemether and lumefantrine. However, the observed kinetic instability (p...

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Comparative study between radiation exposure in common urological procedures

Fluoroscopy has become essential to urological surgery since advancement of endourology. Fluoroscopy use has increased, placing urologists as well as staff members at risk for occupational radiation exposure a...

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Anti-Alzheimer potential of Solanum lycopersicum seeds: in vitro, in vivo, metabolomic, and computational investigations

Solanum lycopersicum Linn. (Tomato, Family Solanaceae) is one of the fruits that are most consumed worldwide. The current research intends to emphasise the possibility of positive and therapeutic effects of S. ly...

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Correlation analysis between polymorphism of leptin and IGFI genes and body measurements in Barki and Farafra sheep

Growth performance, which can be evaluated using various body measurements, is crucial for providing red meat for human consumption. This study aims to improve the growth performance of sheep by identifying th...

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Synthesis and efficacy of cinnamon oil formulations and their sustainable release against common house mosquito larvae

Control of mosquitoes is considered an essential public health priority. This study was designed to estimate the larvicidal activity of two formulations of Cinnamomum zeylanicum EO for controlling Culex pipiens l...

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Fabrication and evaluation of smart pH/thermo dual-responsive injectable intratumoral in situ depot hydrogels for controlled 5-FU delivery

5-FU has multiple applications in various cancers but has limitations owing to its shorter half-life and rapid metabolism. In this study, injectable intratumoral gels were developed to enhance 5-FU concentrati...

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Phenetic and cladistic analyses of Boraginaceae Juss.

The systematics of family Boraginaceae draw attention of many botanists for many years. The current study's primary goals are to clarify phenetic and phylogenetic relationships within Boraginaceae according to...

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Nanotoxicological profiles of clinically approved nanoplatforms

Nanoparticles (NPs) engineering offers great opportunities to produce versatile materials for multiple applications in medicine, including drug delivery and bioimaging. Successful development of nanomedicines ...

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COVID-19-related health literacy and preparedness to what may come: a cross-sectional study

Since the first report of COVID-19 in 2019, information released has been fast and vast. Health literacy focuses on individual skills to obtain, process, and understand health information and services necessar...

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Metabolites of Trichoderma harzianum re-balance T-reg/Th-17 cytokine axis in epileptic rats

Recurrent seizure is synchronous neuronal network hyperexcitation. Even though many anti-epileptic drugs (AEDs) are available, but have several drawbacks, including multiple drug interactions, suboptimal respo...

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The association of claudin-18 and androgen receptor expression in prostatic carcinoma: an immunohistochemical study

Claudin-18 (CLDN18) is a recently identified anticancer therapeutic target with promising results for various gastrointestinal malignancies. The role of CLDN18 in prostatic carcinoma has not been investigated....

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QSAR modeling, molecular docking, dynamic simulation and ADMET study of novel tetrahydronaphthalene derivatives as potent antitubercular agents

Tuberculosis is an air-borne contagious disease caused by slow-growing Mycobacterium tuberculosis (Mtb). According to Global Tuberculosis Report 2022, 1.6 million people were infected by tuberculosis in 2021. The...

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CD72 gene expression in children suffering from primary immune thrombocytopenia and its correlation with the disease activity

Immune thrombocytopenia is a condition in which the immune system attacks platelets, leading to a low platelet count. CD72 is a co-receptor found on B cells during all developmental stages except those of plas...

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SRAP and IRAP revealed molecular characterization and genetic relationships among cowpea (Vigna unguiculata L.) irradiated by gamma-ray

Cowpea is a high-protein legume that can be grown in many environments. Gamma radiation can modify plant metabolism and growth. An experiment was conducted to determine the effect of different gamma-ray doses ...

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Sterols and flavonoids in strawberry calyx with free radical scavenging, anti-inflammatory, and molecular dynamic study

The phytochemical constitution and biological capabilities of Fragaria ananassa's calyx have not been extensively investigated before. Consequently, the research study pointed for characterization, isolation, and...

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Variable cross-sectional effect on bi-directional blades–tower–soil–structure dynamic interaction on offshore wind turbine subject to wind–wave loads

This study introduces a numerical model designed to simulate interactions occurring between a wind turbine's tower and the surrounding soil, as well as between the nacelle, blades, and the surrounding environm...

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Numerical modelling of traffic-induced dynamic loading on a two-story residential building

This paper presents a numerical modelling procedure of dynamic loading due to traffic on a two-story residential building. In developing countries cities and towns, poor quality narrow road sections with high ...

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The alleviative efficacy of sildenafil and chrysin against zinc oxide nanoparticles-provoked hepatic and blood toxicity: role of MyD88/NF-κB1/TNF-α pathway

Zinc oxide nanoparticles are nanoparticles of metal oxide with semiconductor properties and proved many noxious effects on the mammalian cell. Sildenafil, a phosphodiesterase inhibitor, and chrysin, one of the...

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Empagliflozin versus Sitagliptin as add-on dual therapy in Egyptian patients with type 2 diabetes inadequately controlled with Metformin: a 12-week randomized, open-label, parallel-group trial

Diabetes is one of the world’s most widespread conditions, and diabetic patients are among the most likely to engage in fierce battles with this chronic disease. Which group should be added-on as a dual therap...

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Efficacy of polyherbal formulation along with standard care of treatment in early recovery of COVID-19 patients: a randomized placebo-controlled trial

The coronavirus disease-2019 (COVID-19) pandemic crisis has affected millions of people worldwide. The emergence of mutant strains one after the other, breakthrough infections post-vaccination and reinfection ...

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Hydrogen peroxide enhances transforming growth factor beta-2 induced epithelial–mesenchymal transition of ARPE-19 cells

In the pathophysiology of the retina, the epithelial–mesenchymal transition and oxidative stress play key roles. To find a relationship between oxidative stress and diabetic retinopathy or proliferative retino...

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A modified model for laser-cornea interaction following the ablation effect in the laser eye-surgery

Laser corneal reshaping is a successful treatment of many refraction disorders. However, some physical demonstrations for the laser interaction with cornea are not fully explained. In the current paper, we pre...

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Immunogenicity of extracellular proteins of Flavobacterium covae in Ictalurus punctatus

Columnaris disease, instigated by Gram-negative Flavobacterium covae (F. covae), is a dreadful disease of many different genera of freshwater fish with alarmingly high mortality rates. Ictalurus punctatus (I. pun...

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Polydatin nanoparticles attenuate oxidative stress and histopathological changes in streptozotocin model of diabetic nephropathy: targeting Nrf2/HO-1/NF-κβ signaling pathways

One of the most prevalent and serious side effects of diabetes mellitus is diabetic nephropathy, which is characterized by abnormalities in kidney structure that can occur before kidney function declines. Up t...

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Carbapenemase producing Enterobacterales clinical isolates from a tertiary care hospital in Egypt

Carbapenem resistant Enterobacterales (CRE) is on the rise globally, triggering a significant health threat and a substantial concern for infection control management. We aimed to detect and characterize carba...

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Immunohistochemical assessment of the potential behavior of glandular odontogenic cyst and inflammatory periodontal cyst using E-cadherin and N-cadherin

This study is done to evaluate the immunohistochemical expression of E-cadherin and N-cadherin in glandular odontogenic cysts (GOC), inflammatory periodontal (IPDL) cysts, and dental follicles (DF), and if the...

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Endothelium-dependent vasorelaxation effects of F5 fraction of Crinum amabile chloroform extract

Vascular dysfunction can lead to many health problems including hypertension and heart disease. The complexities of vascular dysfunction and vascular disorder-related diseases have prompted the search for many...

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A hybrid B-spline collocation technique for the Caputo time fractional nonlinear Burgers’ equation

This study proposes an efficient and stable technique based on new hybrid B-spline (HB-spline) functions for the numerical treatment of the Caputo time fractional nonlinear Burgers’ (TFNB) equation. The time d...

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Regulation of epithelial-mesenchymal transition in retinal pigment epithelium and its associated cellular signaling cascades: an updated review

The epithelial-mesenchymal transition (EMT) affects the retinal pigment epithelium's natural homeostasis. According to observations from around the world, numerous oculopathies, including proliferative vitreor...

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The modified homotopy perturbation method and its application to the dynamics of price evolution in Caputo-fractional order Black Scholes model

Following a financial loss in trades due to lack of risk management in previous models from market practitioners, Fisher Black and Myron Scholes visited the academic setting and were able to mathematically dev...

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Correction: Efficacy of threshold inspiratory muscle trainer versus diaphragmatic plus pursed lip breathing in occupational COPD

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Characterization and optimization of clove oil-loaded nanomicelles for the possible topical use of bacterial infection-led atopic dermatitis

Atopic dermatitis is an abnormal skin condition that impacts a significant number of people in the US, with an estimated 9.6 million children and 16.5 million adults being affected by it. The study aimed to ch...

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A prototype variable corresponding to the proportion of ischemia for the comparison between robotic and open partial nephrectomy: a meta-analysis accompanied by sensitivity analysis

The primary objective of this study involves the formulation of a novel variable, derived from initial data related to ischemia duration and operative time in partial nephrectomies. The aim was to determine th...

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Study of Cosavirus, Salivirus, and Bufavirus viruses in children with acute gastroenteritis

Acute gastroenteritis (AGE) in children represents a health problem. Besides common enteric viruses such as rotavirus and adenovirus, new viruses such as cosavirus, salivirus, and bufavirus may be associated w...

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The rising burden of chronic kidney diseases in patients with diabetes

The prevalence of chronic kidney diseases (CKD) is higher in patients with diabetes. The American diabetes association (ADA) provides components of diabetes care, treatments, and guidelines to diagnose diabeti...

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Artificial intelligence in diagnosis and management of Huntington’s disease

Huntington’s disease is one of the rare neurodegenerative diseases caused because of genetic mutation of the Huntingtin gene. The major hallmarks of the condition include motor impairment, cognitive decline, a...

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Hydromagnetic flow of micropolar nanofluids with co-effects of thermal radiation and chemical reaction over an inclined permeable stretching surface

Many investigations have been conducted by researchers across the globe to examine the behavior of fluids with respect to the influence of some constituent parameters and novel results have been obtained. Howe...

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